SORBS3 and GLRA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SORBS3	GLRA1
Description		sorbin and SH3 domain containing 3	glycine receptor alpha 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction	Plasma Membrane External Side Of Plasma Membrane Membrane Dendrite Chloride Channel Complex Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Intracellular Membrane-bounded Organelle Synapse Postsynaptic Membrane Inhibitory Synapse Glycinergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Zinc Ion Binding Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Taurine Binding Identical Protein Binding Metal Ion Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Startle Response Regulation Of Respiratory Gaseous Exchange By Nervous System Process Monoatomic Ion Transport Chloride Transport Muscle Contraction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Acrosome Reaction Visual Perception Adult Walking Behavior Neuronal Action Potential Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Respiratory Gaseous Exchange Neuromuscular Process Controlling Posture Neuromuscular Process Negative Regulation Of Transmission Of Nerve Impulse Synaptic Transmission, Glycinergic Righting Reflex Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Response To Alcohol Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Acrosome Reaction
Pathways		Smooth Muscle Contraction	Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs			Glycine Enflurane Lindane Picrotoxin Atropine Isoflurane Ethanol Methoxyflurane Memantine Halothane Desflurane Sevoflurane Ginkgo biloba Zinc Taurine D-Serine GW 468816 Seletracetam Cannabidiol Cannabidiol Copper Thiocolchicoside Medical Cannabis Medical Cannabis Nabiximols Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Hyperekplexia
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Morning person ( 30696823)
Interacting Genes		137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	2 interacting genes: MAGED1 SORBS3
Entrez ID		10174	2741
HPRD ID		11535	00719
Ensembl ID		ENSG00000120896	ENSG00000145888
Uniprot IDs		O60504	P23415 Q14C71
PDB IDs		2CT3 2DLM 2NWM 2YUP	1MOT 1VRY 2M6B 2M6I 4X5T 8DN2 8DN3 8DN4 8DN5
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection
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