CDC23 and BCAS3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CDC23	BCAS3
Gene Name		cell division cycle 23	breast carcinoma amplified sequence 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Cytoplasm Cytoplasmic Microtubule Cell Leading Edge Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity	Chromatin Binding Protein Binding Transcription Factor Binding Acetyltransferase Activator Activity Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Beta-tubulin Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	Angiogenesis Transcription, DNA-templated Golgi Organization Positive Regulation Of Endothelial Cell Migration Vesicle-mediated Transport Microtubule Organizing Center Organization Activation Of Cdc42 GTPase Activity Negative Regulation Of Rho GTPase Activity Tube Formation Response To Starvation Positive Regulation Of Catalytic Activity Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Filopodium Assembly Negative Regulation Of Focal Adhesion Assembly Cellular Response To Estrogen Stimulus Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Cell Polarity Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Chronic kidney disease ( 20383146) Height ( 18391951) Immune reponse to smallpox (secreted IL-2) ( 22610502) Obesity-related traits ( 23251661) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Urate levels ( 23263486) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		44 interactors: ANAPC10 ANAPC13 APOL1 ATRIP BCAS3 BYSL CCDC24 CCDC36 CDC16 CDH1 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SOX5 SPERT SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S	5 interactors: C16orf70 CDC23 CTBP1 CTBP2 ZDHHC17
Entrez ID		8697	54828
HPRD ID		07221	06313
Ensembl ID		ENSG00000094880	ENSG00000141376
Uniprot IDs		Q9UJX2	Q05D99 Q9H6U6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Cell Cycle Regulation Of Organelle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Protein Polyubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Division Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Cell Cycle Checkpoint Protein Modification By Small Protein Conjugation Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Chromosome Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Fat Cell Differentiation Viral Life Cycle Regulation Of Chromosome Organization Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Chromatin Binding Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Histone H4 Acetylation Regulation Of Exit From Mitosis Negative Regulation Of Cellular Metabolic Process Regulation Of Histone H4 Acetylation Viral Process Lipoprotein Transport Positive Regulation Of Histone Deacetylation Magnesium Ion Transport Negative Regulation Of Histone Acetylation Protein K11-linked Ubiquitination Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Positive Regulation Of Protein Deacetylation Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Protein Palmitoylation Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Regulation Of Histone Deacetylation Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chromosome Segregation Establishment Of Chromosome Localization Negative Regulation Of Protein Metabolic Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Histone Acetylation Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Regulation Of Protein Deacetylation Regulation Of Cell Cycle Cellular Protein Modification Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Chromosome Organization
Tagcloud ?		34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Difference) ?		34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Intersection) ?