SORBS3 and NOTCH3

Number of citations of the paper that reports this interaction (PMID 25356737)
0

Data Source:
BioGRID (pull down)

		SORBS3	NOTCH3
Gene Name		sorbin and SH3 domain containing 3	notch 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Golgi Membrane Extracellular Region Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Calcium Ion Binding Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Gene Expression Forebrain Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Glomerular Capillary Formation
Pathways		Smooth Muscle Contraction	Notch-HLH transcription pathway Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing Signaling by NOTCH3
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)
Protein-Protein Interactions		46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	40 interactors: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B MAML1 MAML2 MAML3 MPPED2 MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		10174	4854
HPRD ID		11535	02607
Ensembl ID		ENSG00000120896	ENSG00000074181
Uniprot IDs		O60504	Q9UM47
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process	Notch Signaling Pathway Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Tissue Morphogenesis DNA-templated Transcription, Initiation Morphogenesis Of An Epithelium Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Epithelium Development Positive Regulation Of Metabolic Process Immune System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression System Development Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Hemopoiesis Cell Surface Receptor Signaling Pathway Anatomical Structure Development Cell Fate Commitment Developmental Process Tube Development Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Cell Differentiation Organ Morphogenesis Auditory Receptor Cell Differentiation Heart Morphogenesis Epithelial Tube Morphogenesis Membrane Protein Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Transcription Of Notch Receptor Target Hair Cell Differentiation Auditory Receptor Cell Fate Commitment Stem Cell Development Tube Morphogenesis Myoblast Differentiation Cell Development Endothelial Tube Morphogenesis Generation Of Neurons Notch Signaling Involved In Heart Development Amyloid Precursor Protein Catabolic Process Nervous System Development Stem Cell Maintenance Negative Regulation Of Cell Differentiation Stem Cell Differentiation Inner Ear Receptor Cell Differentiation
Tagcloud ?			barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Difference) ?			barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
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