SORBS3 and CPNE2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SORBS3	CPNE2
Gene Name		sorbin and SH3 domain containing 3	copine II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		HIV-1 control ( 20205591)
Protein-Protein Interactions		46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	18 interactors: ACTB ANXA7 BCOR CDKN1A IKBKG LNX1 MYCBP PDCD6 PPP5C RDX REL SKIL SORBS3 TERF2IP TRIM27 UBA3 UBE2M UBE2O
Entrez ID		10174	221184
HPRD ID		11535	05015
Ensembl ID		ENSG00000120896	ENSG00000140848
Uniprot IDs		O60504	Q96FN4
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process	Protein Modification By Small Protein Conjugation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Protein Neddylation Positive Regulation Of Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Cellular Component Organization Protein Ubiquitination Regulation Of Cellular Process Transcription, DNA-templated Regulation Of Intracellular Signal Transduction RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Protein Oligomerization Protein K63-linked Ubiquitination Protein Trimerization Response To Stress NIK/NF-kappaB Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Protein Monoubiquitination Regulation Of Signal Transduction Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Epithelial Cell Differentiation Regulation Of Cell Death Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Death Fc Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Heat Lymphocyte Homeostasis Retrograde Transport, Endosome To Golgi Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Neuron Death Cellular Protein Modification Process Negative Regulation Of Tooth Mineralization Negative Regulation Of Interleukin-2 Secretion Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
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