CDC23 and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 25306918)
0

Data Source:
BioGRID (pull down)

		CDC23	UBE2S
Description		cell division cycle 23	ubiquitin conjugating enzyme E2 S
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Chromosome Alignment Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		78 interacting genes: ANAPC10 ANKRD11 APOL1 ATRIP BCAS3 BEGAIN BYSL C21orf91 CBY2 CCDC125 CCDC24 CCDC33 CDC16 CDT1 CEP44 CERCAM COIL CRACR2A CRTC2 CTBP1 CYB5R2 DCLK1 DEPDC1B DISC1 DLX6-AS1 EIF5A2 FAM9B FOXN1 GORASP2 GPRASP3 GTPBP8 HEMK1 IHO1 INCA1 INO80E INPP5J KCTD6 KRT36 LHX3 LZTS1 LZTS2 MAGED1 MAPK3 NAB2 NRBF2 NUP54 OPTN PFKFB4 PIH1D2 PNMA5 POU6F2 PROSER3 PRPF31 PRR22 RAC1 RAD54B RBM15B RBP3 RBPMS RSL24D1 RUNX1T1 SIAH1 SLC52A2 SMARCB1 SMUG1 SORBS3 SOX5 SPAG8 SSX2IP STX2 SUV39H1 TEPSIN TNIP1 TRIM27 TSC22D4 UBE2S USP54 ZMAT1	33 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD HECTD3 HERC1 LINC00839 MDM2 NFKBIA OTUB1 OTUD7B PRKN RBCK1 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP2 USP21 USP5 USP7
Entrez ID		8697	27338
HPRD ID		07221	15603
Ensembl ID		ENSG00000094880	ENSG00000108106
Uniprot IDs		Q9UJX2	Q16763
PDB IDs		4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98 7AHF 8TAU
Enriched GO Terms of Interacting Partners?			Post-translational Protein Modification Proteolysis Protein Modification Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Protein Deubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Protein Catabolic Process Protein Branched Polyubiquitination Protein Polyubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cysteine-type Deubiquitinase Activity Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Positive Regulation Of Mitotic Sister Chromatid Separation Cysteine-type Peptidase Activity Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Reproductive Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Cell Cycle Ubiquitin Binding Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Peptidase Activity Regulation Of Mitotic Cell Cycle Phase Transition
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