SORBS3 and SRCIN1

Number of citations of the paper that reports this interaction (PubMedID 18662323)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SORBS3	SRCIN1
Description		sorbin and SH3 domain containing 3	SRC kinase signaling inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction	Cytoplasm Cytoskeleton Focal Adhesion Postsynaptic Density Actin Cytoskeleton Axon Dendrite Cell Projection Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding	Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Exocytosis Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Postsynaptic Actin Cytoskeleton Organization
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Rate of ventricular enlargement ( 31711042)
Interacting Genes		137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	6 interacting genes: ABL1 BCAR1 FBXO7 SNAP25 SORBS3 SRC
Entrez ID		10174	80725
HPRD ID		11535	11589
Ensembl ID		ENSG00000120896	ENSG00000277363
Uniprot IDs		O60504	Q9C0H9
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection	ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell-substrate Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cell Projection Organization Ephrin Receptor Binding Actin Filament Organization Cellular Response To Fluid Shear Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cell Adhesion Response To Fluid Shear Stress SH2 Domain Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Substrate Adhesion-dependent Cell Spreading Autophagy Response To Growth Factor Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Locomotion Regulation Of Focal Adhesion Assembly Cellular Response To Hydrogen Peroxide Regulation Of Mitochondrial Membrane Potential Response To Transforming Growth Factor Beta Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Focal Adhesion Regulation Of Cell-substrate Junction Organization Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Binding Protein Localization To Cytoplasmic Microtubule Plus-end Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite
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