CDC23 and INCA1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CDC23	INCA1
Gene Name		cell division cycle 23	inhibitor of CDK, cyclin A1 interacting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	Negative Regulation Of Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		44 interactors: ANAPC10 ANAPC13 APOL1 ATRIP BCAS3 BYSL CCDC24 CCDC36 CDC16 CDH1 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SOX5 SPERT SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S	33 interactors: ARMC7 CABP5 CCNA1 CDC23 CDK2 CDKN2D CHCHD2 COL8A1 CTNNBIP1 DMRT3 EPHB6 FAM103A1 FHL2 FMR1 GRB2 HAUS1 NEK6 OSGIN1 PATE1 PTGER3 RBPMS SAP18 SCNM1 SEC14L4 SPG21 STAMBPL1 STK16 TRIP6 UBE2D4 UBXN2B VPS28 ZMYND19 ZNF205-AS1
Entrez ID		8697	388324
HPRD ID		07221	17150
Ensembl ID		ENSG00000094880	ENSG00000196388
Uniprot IDs		Q9UJX2	Q0VD86
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K11-linked Ubiquitination Cell Cycle Regulation Of Organelle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Protein Polyubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Division Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Cell Cycle Checkpoint Protein Modification By Small Protein Conjugation Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Mitotic Nuclear Division Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein K11-linked Ubiquitination G1/S Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Recruitment Of MRNA Capping Enzyme To RNA Polymerase II Holoenzyme Complex Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Process Cell Cycle Checkpoint Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Modification-dependent Protein Catabolic Process Nuclear Envelope Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Acute Inflammatory Response Atrial Cardiac Muscle Cell Development Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cell Cycle Regulation Of Cell Cycle Cellular Protein Catabolic Process Gene Expression Spindle Assembly RNA Processing Positive Regulation Of DNA-dependent DNA Replication Initiation Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Fever Generation
Tagcloud ?		34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine	accompanied arrest bax bcl2 birc5 ccna1 cdk2 cdkn1a deregulation entering g2 lats2 microrna mir modification namely nasopharyngeal nine npc phenotypes possibly precursor preliminary progression suppressing tp53 transfected tw01 words
Tagcloud (Difference) ?		34c annexin atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic incorporation inducing influenced mediator mimicked mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine	accompanied bax bcl2 birc5 ccna1 cdk2 cdkn1a deregulation entering lats2 modification namely nasopharyngeal nine npc phenotypes possibly precursor preliminary progression suppressing tp53 transfected tw01 words
Tagcloud (Intersection) ?		arrest g2 microrna mir