SORBS3 and PPFIA3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SORBS3	PPFIA3
Name		sorbin and SH3 domain containing 3	PPFI scaffold protein A3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction	Acrosomal Vesicle Cytoplasm Cytosol Cytoplasmic Vesicle Synapse Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Epididymosome Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Neurotransmitter Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization
Pathways		Smooth Muscle Contraction	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
GWAS		Diastolic blood pressure ( 30224653 ) HIV-1 viral setpoint ( 20205591 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Parkinson's disease ( 28892059 )	Adult body size ( 32376654 ) Leukoderma in response to rhododendrol ( 32558222 )
Novel Interactors		1 novel interactors: PPP3CC	1 novel interactors: ATP1A3
Interacting Genes		137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414	17 interacting genes: CAST CBY2 CNKSR1 DISC1 ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PPP1R13B PTPRD PTPRF PTPRS PTPRU SORBS3 TFIP11
Entrez ID		10174	8541
HPRD ID		11535	04393
Ensembl ID		ENSG00000120896	ENSG00000177380
Uniprot IDs		O60504	O75145
PDB IDs		2CT3 2DLM 2NWM 2YUP	Not available
GO Terms Enriched among Interactors		Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection	Presynaptic Active Zone Synapse Organization Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Regulation Of Dendritic Spine Development Cell Junction Organization Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Adhesion Synaptic Membrane Adhesion Protein Tyrosine Phosphatase Activity Maintenance Of Synapse Structure Presynaptic Membrane Phosphoprotein Phosphatase Activity Regulation Of Postsynapse Organization Glutamatergic Synapse Cell Junction Maintenance Cortical Microtubule Organization Axon Presynaptic Active Zone Organization Cellular Component Maintenance Maintenance Of Postsynaptic Specialization Structure Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Presynapse Protein Dephosphorylation Regulation Of Postsynaptic Density Assembly Modulation Of Chemical Synaptic Transmission Postsynaptic Density Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Presynapse Organization Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Synapse Postsynaptic Specialization Organization Dephosphorylation Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cell-substrate Adhesion Neuromuscular Junction Development Regulation Of Response To Wounding Cell Cortex Focal Adhesion Regulation Of Dendritic Spine Morphogenesis