SVEP1 and SMAD9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SVEP1	SMAD9
Description		sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	SMAD family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Chromatin Binding Integrin Binding Calcium Ion Binding Protein Binding Integrin Binding Involved In Cell-matrix Adhesion	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding I-SMAD Binding
	Biological Process	Lymph Vessel Development Circulatory System Process Lymph Circulation Cell Adhesion Cell-matrix Adhesion Epidermis Development Gene Expression Positive Regulation Of Platelet Activation Lymph Vessel Morphogenesis Negative Regulation Of Vasoconstriction Tie Signaling Pathway Negative Regulation Of Multicellular Organismal Process Tight Junction Organization	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Pathways			Signaling by BMP
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Longevity ( 20834067) Mean arterial pressure ( 27618448) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metamizole-induced agranulocytosis ( 33138277) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 27618448 30578418 27841878) Takayasu arteritis ( 33308445) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Coronary artery disease ( 29212778) Heel bone mineral density ( 28869591 30598549) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)
Interacting Genes		7 interacting genes: ATF7IP KLHL20 MTNR1A SKIL SMAD3 SMAD9 ZFYVE9	117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SKIC3 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		79987	4093
HPRD ID		12942	04484
Ensembl ID		ENSG00000165124	ENSG00000120693
Uniprot IDs		B3KQM1 Q4LDE5 Q5JB40	O15198
PDB IDs			6FZT
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Regulator Complex SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Lens Fiber Cell Differentiation SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Type II Interferon Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Protein K33-linked Ubiquitination PML Body Sterol Response Element Binding Extrinsic Apoptotic Signaling Pathway Paraxial Mesoderm Morphogenesis Osteoblast Differentiation Regulation Of Lung Blood Pressure Melatonin Receptor Activity	Macromolecule Metabolic Process Ameboidal-type Cell Migration Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Regulation Of SMAD Protein Signal Transduction Regulation Of Gene Expression Macromolecule Biosynthetic Process SMAD Protein Complex Protein Metabolic Process Regulation Of RNA Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process R-SMAD Binding Histone Methyltransferase Complex Proteolysis Activin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process MLL3/4 Complex Endoderm Development Catabolic Process Protein Catabolic Process Regionalization Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Autophagosome Maturation Golgi Apparatus Mannose Trimming Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Organelle Organization Ventricular Septum Morphogenesis
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