SVEP1 and KLHL20

Number of citations of the paper that reports this interaction (PubMedID 26687681)
0

Data Source:
BioGRID (two hybrid)

		SVEP1	KLHL20
Description		sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	kelch like family member 20
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Membrane	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Integrin Binding Calcium Ion Binding Protein Binding Integrin Binding Involved In Cell-matrix Adhesion	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Lymph Vessel Development Circulatory System Process Lymph Circulation Cell Adhesion Cell-matrix Adhesion Epidermis Development Gene Expression Positive Regulation Of Platelet Activation Lymph Vessel Morphogenesis Negative Regulation Of Vasoconstriction Tie Signaling Pathway Negative Regulation Of Multicellular Organismal Process Tight Junction Organization	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Longevity ( 20834067) Mean arterial pressure ( 27618448) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metamizole-induced agranulocytosis ( 33138277) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 27618448 30578418 27841878) Takayasu arteritis ( 33308445) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Feeling miserable ( 29500382)
Interacting Genes		7 interacting genes: ATF7IP KLHL20 MTNR1A SKIL SMAD3 SMAD9 ZFYVE9	81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT
Entrez ID		79987	27252
HPRD ID		12942	13918
Ensembl ID		ENSG00000165124	ENSG00000076321
Uniprot IDs		B3KQM1 Q4LDE5 Q5JB40	Q9Y2M5
PDB IDs			5YQ4 6GY5 8CIA
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Regulator Complex SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Lens Fiber Cell Differentiation SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Type II Interferon Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Protein K33-linked Ubiquitination PML Body Sterol Response Element Binding Extrinsic Apoptotic Signaling Pathway Paraxial Mesoderm Morphogenesis Osteoblast Differentiation Regulation Of Lung Blood Pressure Melatonin Receptor Activity	Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I
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