SVEP1

Description		sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Membrane
	Molecular Function	Chromatin Binding Integrin Binding Calcium Ion Binding Protein Binding Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Lymph Vessel Development Circulatory System Process Lymph Circulation Cell Adhesion Cell-matrix Adhesion Epidermis Development Gene Expression Positive Regulation Of Platelet Activation Lymph Vessel Morphogenesis Negative Regulation Of Vasoconstriction Tie Signaling Pathway Negative Regulation Of Multicellular Organismal Process Tight Junction Organization
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Longevity ( 20834067) Mean arterial pressure ( 27618448) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metamizole-induced agranulocytosis ( 33138277) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 27618448 30578418 27841878) Takayasu arteritis ( 33308445) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Novel Interacting Genes		1 novel interacting genes: FKBP15
Interacting Genes		7 interacting genes: ATF7IP KLHL20 MTNR1A SKIL SMAD3 SMAD9 ZFYVE9
Entrez ID		79987
HPRD ID		12942
Ensembl ID		ENSG00000165124
Uniprot IDs		B3KQM1 Q4LDE5 Q5JB40
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Regulator Complex SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding Lens Fiber Cell Differentiation SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Response To Growth Factor Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Type II Interferon Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Protein K33-linked Ubiquitination PML Body Sterol Response Element Binding Extrinsic Apoptotic Signaling Pathway Paraxial Mesoderm Morphogenesis Osteoblast Differentiation Regulation Of Lung Blood Pressure Melatonin Receptor Activity
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