SVEP1 and ZFYVE9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SVEP1	ZFYVE9
Gene Name		sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	zinc finger, FYVE domain containing 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Early Endosome Early Endosome Membrane
	Molecular Function	Calcium Ion Binding	Protein Binding 1-phosphatidylinositol Binding Serine-type Peptidase Activity Metal Ion Binding
	Biological Process	Cell Adhesion	Proteolysis Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Longevity ( 20834067) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Protein-Protein Interactions		5 interactors: ATF7IP SKIL SMAD3 SMAD9 ZFYVE9	38 interactors: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBB2IP ETS2 FAM46A FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPG20 ST7 SUMF2 SUPT5H SVEP1 TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		79987	9372
HPRD ID		12942	04782
Ensembl ID		ENSG00000165124	ENSG00000157077
Uniprot IDs		B3KQM1 Q4LDE5 Q5JB40	O95405
PDB IDs			1DEV 1MK2 4BKW
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Lens Fiber Cell Differentiation Lens Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Transforming Growth Factor Beta3 Production Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Transcription, DNA-templated Kidney Epithelium Development Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Response To Organic Substance Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Apoptotic Signaling Pathway Protein Complex Assembly Regulation Of Gene Expression, Epigenetic Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Transcription, DNA-templated Epithelium Development DNA-templated Transcription, Initiation Negative Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Extracellular Matrix Assembly Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Surface Receptor Signaling Pathway Response To Hypoxia	Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Common-partner SMAD Protein Phosphorylation Cell Cycle Trachea Formation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Embryonic Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Embryonic Cranial Skeleton Morphogenesis Cellular Response To Organic Substance Response To Organic Substance Photoperiodism Entrainment Of Circadian Clock Embryonic Skeletal System Development Lens Development In Camera-type Eye Cell Cycle Process Regulation Of Growth Signal Transduction Trachea Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Embryonic Foregut Morphogenesis Regulation Of Gene Expression Foregut Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Lung Development Negative Regulation Of Growth Negative Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Respiratory Tube Development Glycogen Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Skeletal System Morphogenesis Tube Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Death
Tagcloud ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Difference) ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Intersection) ?