CHPF and SMAD9

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		CHPF	SMAD9
Gene Name		chondroitin polymerizing factor	SMAD family member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Matrix Cytosol Integral Component Of Membrane Golgi Cisterna Membrane	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Small Molecule Metabolic Process	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARHGEF5 BTRC EXOSC10 EXOSC6 NKX3-1 PARK2 PIN1 SKIL SMAD9	117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		79586	4093
HPRD ID		10829	04484
Ensembl ID		ENSG00000123989	ENSG00000120693
Uniprot IDs		Q8IZ52	O15198
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Response To Organic Substance Positive Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Response To Organic Cyclic Compound Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity RNA Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Epithelium Development Epithelial Cell Proliferation Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Lipid Transport Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Androgen Secretion Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Catalytic Activity Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Response To DNA Damage Stimulus Cell Cycle RRNA Processing Cell Communication	Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process
Tagcloud ?		ab aorta aortic ascending banding chondroitin cxcl16 db debanding declining decorin fibrogenesis gag glycosaminoglycan glycosylated gradual keratan lumican oligosaccharides overload polymerizing proteoglycans remodeling served sevenfold slrps stenosis synthesizing valve
Tagcloud (Difference) ?		ab aorta aortic ascending banding chondroitin cxcl16 db debanding declining decorin fibrogenesis gag glycosaminoglycan glycosylated gradual keratan lumican oligosaccharides overload polymerizing proteoglycans remodeling served sevenfold slrps stenosis synthesizing valve
Tagcloud (Intersection) ?