CHPF and NKX3-1

Number of citations of the paper that reports this interaction (PMID 18816836)
2

Data Source:
BioGRID (two hybrid)

		CHPF	NKX3-1
Gene Name		chondroitin polymerizing factor	NK3 homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Matrix Cytosol Integral Component Of Membrane Golgi Cisterna Membrane	Intracellular Nucleus
	Molecular Function	Protein Binding Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Androgen Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Protein Kinase Activator Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association Transcription Regulatory Region DNA Binding MADS Box Domain Binding
	Biological Process	Carbohydrate Metabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Small Molecule Metabolic Process	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Salivary Gland Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Hormone Mediated Signaling Pathway Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARHGEF5 BTRC EXOSC10 EXOSC6 NKX3-1 PARK2 PIN1 SKIL SMAD9	32 interactors: AEN CCT7 CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 ND4 PEBP1 PTMS RABL6 RARG RPL37A RPSA SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 STRA13 TEX264 TOPORS TPT1 WDR77
Entrez ID		79586	4824
HPRD ID		10829	03620
Ensembl ID		ENSG00000123989	ENSG00000167034
Uniprot IDs		Q8IZ52	Q99801
PDB IDs			2L9R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Response To Organic Substance Positive Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Response To Organic Cyclic Compound Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity RNA Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Epithelium Development Epithelial Cell Proliferation Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Lipid Transport Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Androgen Secretion Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Catalytic Activity Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Response To DNA Damage Stimulus Cell Cycle RRNA Processing Cell Communication	Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Embryonic Eye Morphogenesis Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Embryonic Camera-type Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Eye Morphogenesis Biosynthetic Process Megakaryocyte Differentiation Trophectodermal Cell Differentiation Camera-type Eye Development Eye Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Erythrocyte Differentiation Erythrocyte Homeostasis Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Camera-type Eye Morphogenesis Organ Morphogenesis Myeloid Cell Homeostasis Organ Development Embryonic Organ Development Glandular Epithelial Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Embryonic Process Involved In Female Pregnancy Sensory Organ Development Prostate Gland Development Regulation Of RNA Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Tissue Development System Development Homeostasis Of Number Of Cells
Tagcloud ?		ab aorta aortic ascending banding chondroitin cxcl16 db debanding declining decorin fibrogenesis gag glycosaminoglycan glycosylated gradual keratan lumican oligosaccharides overload polymerizing proteoglycans remodeling served sevenfold slrps stenosis synthesizing valve
Tagcloud (Difference) ?		ab aorta aortic ascending banding chondroitin cxcl16 db debanding declining decorin fibrogenesis gag glycosaminoglycan glycosylated gradual keratan lumican oligosaccharides overload polymerizing proteoglycans remodeling served sevenfold slrps stenosis synthesizing valve
Tagcloud (Intersection) ?