CHPF and LCOR

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CHPF	LCOR
Description		chondroitin polymerizing factor	ligand dependent nuclear receptor corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Matrix Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
	Biological Process	Chondroitin Sulfate Proteoglycan Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways		CS-GAG biosynthesis
Drugs
Diseases
GWAS			Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)
Interacting Genes		11 interacting genes: ARHGEF5 BTRC EXOSC10 EXOSC6 LCOR LINC00839 NKX3-1 PIN1 PRKN SKIL SMAD9	144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE
Entrez ID		79586	84458
HPRD ID		10829	07609
Ensembl ID		ENSG00000123989	ENSG00000196233
Uniprot IDs		Q8IZ52	Q96JN0
PDB IDs			2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Activator Activity Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing Nuclear MRNA Surveillance Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Beta-catenin Binding Ubiquitin-specific Protease Binding Regulation Of Dopamine Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Histone Deacetylase Binding Protein K6-linked Ubiquitination Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nuclear Estrogen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway MADS Box Domain Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Regulation Of Protein Targeting To Mitochondrion Cis-trans Isomerase Activity RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Regulation Of Primary Metabolic Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Dorsal Aorta Development Positive Regulation Of Retrograde Transport, Endosome To Golgi SCF Ubiquitin Ligase Complex Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination	Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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