CHPF and ARHGEF5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CHPF	ARHGEF5
Gene Name		chondroitin polymerizing factor	Rho guanine nucleotide exchange factor (GEF) 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Mitochondrial Matrix Cytosol Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding
	Biological Process	Carbohydrate Metabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Small Molecule Metabolic Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Rho GTPase Activity Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Podosome Assembly
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		9 interactors: ARHGEF5 BTRC EXOSC10 EXOSC6 NKX3-1 PARK2 PIN1 SKIL SMAD9	15 interactors: APP ATP13A1 CALCOCO2 CCNE1 CHPF CRKL EFHC2 FKBP8 GRB2 HSPBAP1 NR4A1 PLCG1 SEPHS2 TRIM27 TRIM54
Entrez ID		79586	7984
HPRD ID		10829	02932
Ensembl ID		ENSG00000123989	ENSG00000050327
Uniprot IDs		Q8IZ52	Q12774
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Response To Organic Substance Positive Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Response To Organic Cyclic Compound Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity RNA Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Epithelium Development Epithelial Cell Proliferation Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Lipid Transport Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Androgen Secretion Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Catalytic Activity Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Response To DNA Damage Stimulus Cell Cycle RRNA Processing Cell Communication	Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Immune System Process Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Intracellular Receptor Signaling Pathway Viral Process Regulation Of Protein Phosphorylation Cellular Response To Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Chemotaxis Response To Growth Factor Regulation Of Cellular Protein Metabolic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Selenocysteine Biosynthetic Process Activation Of MAPKK Activity Signaling Cell Communication Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Selenium Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Blood Coagulation Hemostasis Positive Regulation Of Actin Filament Polymerization Collateral Sprouting In Absence Of Injury Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Polymerization
Tagcloud ?		ab aorta aortic ascending banding chondroitin cxcl16 db debanding declining decorin fibrogenesis gag glycosaminoglycan glycosylated gradual keratan lumican oligosaccharides overload polymerizing proteoglycans remodeling served sevenfold slrps stenosis synthesizing valve
Tagcloud (Difference) ?		ab aorta aortic ascending banding chondroitin cxcl16 db debanding declining decorin fibrogenesis gag glycosaminoglycan glycosylated gradual keratan lumican oligosaccharides overload polymerizing proteoglycans remodeling served sevenfold slrps stenosis synthesizing valve
Tagcloud (Intersection) ?