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VCP and NDRG1
Number of citations of the paper that reports this interaction (PubMedID
17220478
)
0
Data Source:
HPRD
(in vivo)
VCP
NDRG1
Description
valosin containing protein
N-myc downstream regulated 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytosol
Cytoplasmic Stress Granule
Protein-containing Complex
VCP-NPL4-UFD1 AAA ATPase Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Site Of Double-strand Break
Ciliary Basal Body
Derlin-1 Retrotranslocation Complex
Intracellular Membrane-bounded Organelle
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Ficolin-1-rich Granule Lumen
ATPase Complex
VCP-NSFL1C Complex
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Adherens Junction
Microtubule Cytoskeleton
Membrane
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Extracellular Exosome
Molecular Function
Nucleotide Binding
RNA Binding
Protein Binding
ATP Binding
Lipid Binding
Hydrolase Activity
ATP Hydrolysis Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Deubiquitinase Activator Activity
K48-linked Polyubiquitin Modification-dependent Protein Binding
MHC Class I Protein Binding
Identical Protein Binding
ADP Binding
Ubiquitin-like Protein Ligase Binding
Protein-containing Complex Binding
Ubiquitin-modified Protein Reader Activity
BAT3 Complex Binding
Ubiquitin-specific Protease Binding
Protein Binding
Microtubule Binding
Nickel Cation Binding
Small GTPase Binding
Gamma-tubulin Binding
Cadherin Binding
Biological Process
DNA Repair
Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Autophagy
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Proteasomal Protein Catabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Macroautophagy
Protein Ubiquitination
Viral Genome Replication
NAD+ Metabolic Process
Translesion Synthesis
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
Cellular Response To Heat
Negative Regulation Of Hippo Signaling
Stress Granule Disassembly
Interstrand Cross-link Repair
ERAD Pathway
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Establishment Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Smoothened Signaling Pathway
ATP Metabolic Process
Regulation Of Synapse Organization
Mitotic Spindle Disassembly
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Aggresome Assembly
Cellular Response To Misfolded Protein
Flavin Adenine Dinucleotide Catabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Autophagosome Maturation
Protein-DNA Covalent Cross-linking Repair
Negative Regulation Of Protein Localization To Chromatin
Cytoplasm Protein Quality Control
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein K63-linked Deubiquitination
Regulation Of Aerobic Respiration
Cellular Response To Arsenite Ion
Positive Regulation Of Oxidative Phosphorylation
Regulation Of Protein Localization To Chromatin
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of ATP Biosynthetic Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Response To Metal Ion
DNA Damage Response, Signal Transduction By P53 Class Mediator
Peripheral Nervous System Myelin Maintenance
Mast Cell Activation
Cellular Response To Hypoxia
Pathways
Translesion Synthesis by POLH
HSF1 activation
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Defective CFTR causes cystic fibrosis
Josephin domain DUBs
Ovarian tumor domain proteases
Neutrophil degranulation
E3 ubiquitin ligases ubiquitinate target proteins
Protein methylation
Neddylation
RHOH GTPase cycle
Aggrephagy
Attachment and Entry
Attachment and Entry
KEAP1-NFE2L2 pathway
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Phenethyl Isothiocyanate
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Response to quetiapine in schizophrenia (
29503163
)
Estimated glomerular filtration rate (
31015462
)
Left-handedness (
32989287
)
Nontyphoidal Salmonella bacteraemia (
29523850
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Interacting Genes
98 interacting genes:
ABHD17C
AMFR
ANKRD13A
AR
ASPSCR1
ATG5
ATXN1
ATXN3
ATXN7
BAG5
BRCA1
BRSK2
BUD23
CACNA1C
CEP19
CLUAP1
CRMP1
CSTF1
DERL1
DGCR6
DTNB
ELAVL1
EPHB4
EPSTI1
ESR1
GZMK
HDAC6
HTT
INSIG1
INSIG2
JAK2
LINC01554
LNX1
LZIC
MAPK8IP2
MDM2
METTL17
NDRG1
NF1
NFKBIA
NGLY1
NOD2
NSFL1C
NTAQ1
NUB1
OPTN
PBK
PIK3R3
PLAA
PPP1CC
PPP1R11
PPP1R3A
PPP1R7
PRKCD
PSMA1
PSMC1
PTPN3
RIPK4
RNF10
RNF115
RNF19A
RNF8
RPS6KA1
SELENOS
SH2D2A
SLC43A3
SNCA
SPRTN
STUB1
STX5
SUMO4
SVIP
TMUB1
TOM1L1
TOMM34
TRIM54
UBASH3A
UBC
UBE4A
UBE4B
UBOX5
UBXN10
UBXN11
UBXN2B
UBXN4
UBXN6
UFD1
USP7
VAMP2
VANGL2
VCF1
VCPIP1
VCPKMT
WAC
WRN
XAF1
YWHAZ
ZBTB25
71 interacting genes:
ACSL3
ACTG1
AP1M2
AP2M1
APOA1
APOA2
ARL4D
ATP1A1
CANX
CDH1
CLTC
CNDP2
COPB2
CTNNB1
DDX1
DDX5
DLST
EEF1G
EEF2
EIF2S3
EIF3E
ETS2
EWSR1
FASN
GSK3B
HNRNPF
HNRNPH1
HNRNPU
HSD17B4
HSP90AA1
HSPA5
ILF3
KIF5B
LDHA
MAOA
MLH1
MME
MYC
NCL
NR4A1
PABPC1
PHYHIP
PKM
PPP2R2A
PRKACA
PSMC2
PSMC3
PSMD2
RPL24
RPL3
RPL4
RPN2
RPS16
RPS20
RPS26
RPS3
RPS6
RPS8
RTN1
RUVBL2
S100B
SEC23A
SGK1
SHMT2
TAF9
TARS1
TLE3
UPF1
VCP
XRCC5
ZNF155
Entrez ID
7415
10397
HPRD ID
03013
05586
Ensembl ID
ENSG00000165280
ENSG00000104419
Uniprot IDs
C9JUP7
P55072
Q8N959
Q92597
PDB IDs
3EBB
3HU1
3HU2
3HU3
3QC8
3QQ7
3QQ8
3QWZ
3TIW
4KDI
4KDL
4KLN
4KO8
4KOD
4P0A
5B6C
5C18
5C19
5C1A
5C1B
5DYG
5DYI
5EPP
5FTJ
5FTK
5FTL
5FTM
5FTN
5GLF
5IFS
5IFW
5KIW
5KIY
5X4L
6G2V
6G2W
6G2X
6G2Y
6G2Z
6G30
6HD0
6MCK
7BP8
7BP9
7BPA
7BPB
7JY5
7K56
7K57
7K59
7L5W
7L5X
7LMY
7LMZ
7LN0
7LN1
7LN2
7LN3
7LN4
7LN5
7LN6
7MDM
7MDO
7MHS
7OAT
7PUX
7R7S
7R7T
7R7U
7RL6
7RL7
7RL9
7RLA
7RLB
7RLC
7RLD
7RLF
7RLG
7RLH
7RLI
7RLJ
7VCS
7VCT
7VCU
7VCV
7VCX
7Y4W
7Y53
7Y59
8B5R
8FCL
8FCM
8FCN
8FCO
8FCP
8FCQ
8FCR
8FCT
8HL7
8HRZ
8KG2
8OOI
8PQX
8R0E
8RS9
8RSB
8RSC
8UV2
8UVO
8UVP
8UVQ
8VKU
8VLS
8VOV
8YKA
9BOQ
6ZMM
Enriched GO Terms of Interacting Partners
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Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
ERAD Pathway
Catabolic Process
Ubiquitin Binding
Cellular Response To Stress
Macromolecule Metabolic Process
Post-translational Protein Modification
ATPase Binding
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Negative Regulation Of Signal Transduction
Protein Modification Process
Cellular Response To Misfolded Protein
Positive Regulation Of Catabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Response To Misfolded Protein
Response To Endoplasmic Reticulum Stress
Cellular Response To Topologically Incorrect Protein
Ubiquitin Protein Ligase Activity
Response To Stress
Ubiquitin-ubiquitin Ligase Activity
Intracellular Signal Transduction
Cytoplasm
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Autophagy
Cytosol
Ubiquitin Protein Ligase Binding
Regulation Of Intracellular Protein Transport
Regulation Of Protein Localization
Regulation Of Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Response To Stress
Regulation Of Intracellular Transport
Golgi Organization
Nucleus
Protein Polyubiquitination
Postsynapse
Protein Binding
Negative Regulation Of Proteolysis
Ribonucleoprotein Complex
Extracellular Exosome
Cytosol
RNA Binding
Macromolecule Metabolic Process
Translation
Cytosolic Ribosome
Macromolecule Biosynthetic Process
Cadherin Binding
Response To Cytokine
Protein Metabolic Process
Response To Peptide
Secretory Granule Lumen
Cellular Response To Cytokine Stimulus
Cytoplasmic Translation
Membrane
Nucleoplasm
ATP Hydrolysis Activity
Regulation Of Protein Metabolic Process
Ribosome
Nucleobase-containing Compound Metabolic Process
Cytosolic Small Ribosomal Subunit
Structural Constituent Of Ribosome
Regulation Of Primary Metabolic Process
Small Ribosomal Subunit
Nucleotide Binding
Protein-RNA Complex Assembly
Regulation Of Translation
ATP Binding
Nucleic Acid Metabolic Process
Regulation Of Telomere Maintenance
Protein Binding
Catabolic Process
RNA Metabolic Process
Positive Regulation Of Cytoplasmic Translation
Ficolin-1-rich Granule Lumen
Protein-containing Complex Organization
Regulation Of RNA Splicing
Macromolecule Catabolic Process
Cytoplasm
Focal Adhesion
Positive Regulation Of Biosynthetic Process
Nucleus
Plasma Lipoprotein Particle Assembly
Protein-lipid Complex Assembly
Disordered Domain Specific Binding
Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Regulation Of Metabolic Process
Post-transcriptional Regulation Of Gene Expression
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