NDRG1 and PPP2R2A

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		NDRG1	PPP2R2A
Description		N-myc downstream regulated 1	protein phosphatase 2 regulatory subunit Balpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	Protein Binding Protein Phosphatase Regulator Activity Protein-containing Complex Binding Tau Protein Binding Protein Phosphatase 2A Binding Enzyme-substrate Adaptor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Protein Dephosphorylation Response To Morphine Regulation Of Chromosome Segregation
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Initiation of Nuclear Envelope (NE) Reformation Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Declining hemoglobin trajectory in blood donors ( 33491795) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 23563607) Schizophrenia ( 28991256) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155	13 interacting genes: BRAF CHEK2 CREBBP GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1
Entrez ID		10397	5520
HPRD ID		05586	09223
Ensembl ID		ENSG00000104419	ENSG00000221914
Uniprot IDs		Q8N959 Q92597	A0A140VJT0 A0A590UJJ1 P63151
PDB IDs		6ZMM	3DW8 8SO0 8TTB 8TWE
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Negative Regulation Of Hippo Signaling Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Signal Transduction Regulation Of Hippo Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Positive Regulation Of Stress Fiber Assembly Signal Transduction Negative Regulation Of Intracellular Signal Transduction NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Intracellular Signal Transduction Excitatory Chemical Synaptic Transmission Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Meiotic Sister Chromatid Cohesion Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spindle Assembly Regulation Of Stress Fiber Assembly Regulation Of Cellular Response To Heat Vascular Endothelial Cell Response To Fluid Shear Stress Signal Transduction By P53 Class Mediator Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction INTAC Complex Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Amino Acid Regulation Of Signal Transduction By P53 Class Mediator Serine/threonine Protein Kinase Complex RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of RNA Metabolic Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Synaptic Transmission
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