NDRG1 and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		NDRG1	AP2M1
Description		N-myc downstream regulated 1	adaptor related protein complex 2 subunit mu 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Major depressive disorder ( 22472876)
Interacting Genes		71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		10397	1173
HPRD ID		05586	03014
Ensembl ID		ENSG00000104419	ENSG00000161203
Uniprot IDs		Q8N959 Q92597	B4DNB9 E9PFW3 Q96CW1
PDB IDs		6ZMM	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex
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