NDRG1 and FASN

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		NDRG1	FASN
Gene Name		N-myc downstream regulated 1	fatty acid synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding	Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH, B-specific) Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding Drug Binding Zinc Ion Binding Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Protein Homodimerization Activity Poly(A) RNA Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity NADPH Binding
	Biological Process	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint	Osteoblast Differentiation Acetyl-CoA Metabolic Process Energy Reserve Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Pantothenate Metabolic Process Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cellular Response To Interleukin-4
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Metabolism of lipids and lipoproteins ChREBP activates metabolic gene expression Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Regulation of cholesterol biosynthesis by SREBP (SREBF) Fatty Acyl-CoA Biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Triglyceride Biosynthesis Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Fatty acid, triacylglycerol, and ketone body metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Activation of gene expression by SREBF (SREBP) Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs			Cerulenin Orlistat
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155	4 interactors: EWSR1 NDRG1 PRR12 YWHAQ
Entrez ID		10397	2194
HPRD ID		05586	02567
Ensembl ID		ENSG00000104419	ENSG00000169710
Uniprot IDs		Q8N959 Q92597	P49327
PDB IDs			1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Positive Regulation Of Spindle Checkpoint Positive Regulation Of Cell Cycle Checkpoint Peripheral Nervous System Myelin Maintenance Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Spindle Checkpoint Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Myelin Maintenance Membrane Organization Mast Cell Activation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Substantia Nigra Development
Tagcloud ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	acc adipose adiposity carboxylase coa conceivable db depot dio distension distortion epidemiologic follicular hypofunction hypothyroidism intrathyroidal lipogenesis ob obese peroxisome proliferator srebp steatosis sterol synthetase systemically thyroid ultrastructural uniformly
Tagcloud (Difference) ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	acc adipose adiposity carboxylase coa conceivable db depot dio distension distortion epidemiologic follicular hypofunction hypothyroidism intrathyroidal lipogenesis ob obese peroxisome proliferator srebp steatosis sterol synthetase systemically thyroid ultrastructural uniformly
Tagcloud (Intersection) ?