VCP and TRIM54

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		VCP	TRIM54
Description		valosin containing protein	tripartite motif containing 54
Image
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Cytoplasmic Stress Granule Protein-containing Complex VCP-NPL4-UFD1 AAA ATPase Complex Secretory Granule Lumen Azurophil Granule Lumen Site Of Double-strand Break Ciliary Basal Body Derlin-1 Retrotranslocation Complex Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Ficolin-1-rich Granule Lumen ATPase Complex VCP-NSFL1C Complex	Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Lipid Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity K48-linked Polyubiquitin Modification-dependent Protein Binding MHC Class I Protein Binding Identical Protein Binding ADP Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Protein Binding Microtubule Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy DNA Damage Response Canonical NF-kappaB Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Potential Macroautophagy Protein Ubiquitination Viral Genome Replication NAD+ Metabolic Process Translesion Synthesis Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cellular Response To Heat Negative Regulation Of Hippo Signaling Stress Granule Disassembly Interstrand Cross-link Repair ERAD Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway ATP Metabolic Process Regulation Of Synapse Organization Mitotic Spindle Disassembly Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Aggresome Assembly Cellular Response To Misfolded Protein Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Autophagosome Maturation Protein-DNA Covalent Cross-linking Repair Negative Regulation Of Protein Localization To Chromatin Cytoplasm Protein Quality Control Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Cellular Response To Arsenite Ion Positive Regulation Of Oxidative Phosphorylation Regulation Of Protein Localization To Chromatin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP Biosynthetic Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell Differentiation Innate Immune Response
Pathways		Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation Neddylation RHOH GTPase cycle Aggrephagy Attachment and Entry Attachment and Entry KEAP1-NFE2L2 pathway AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Phenethyl Isothiocyanate
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Response to quetiapine in schizophrenia ( 29503163)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		98 interacting genes: ABHD17C AMFR ANKRD13A AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BAG5 BRCA1 BRSK2 BUD23 CACNA1C CEP19 CLUAP1 CRMP1 CSTF1 DERL1 DGCR6 DTNB ELAVL1 EPHB4 EPSTI1 ESR1 GZMK HDAC6 HTT INSIG1 INSIG2 JAK2 LINC01554 LNX1 LZIC MAPK8IP2 MDM2 METTL17 NDRG1 NF1 NFKBIA NGLY1 NOD2 NSFL1C NTAQ1 NUB1 OPTN PBK PIK3R3 PLAA PPP1CC PPP1R11 PPP1R3A PPP1R7 PRKCD PSMA1 PSMC1 PTPN3 RIPK4 RNF10 RNF115 RNF19A RNF8 RPS6KA1 SELENOS SH2D2A SLC43A3 SNCA SPRTN STUB1 STX5 SUMO4 SVIP TMUB1 TOM1L1 TOMM34 TRIM54 UBASH3A UBC UBE4A UBE4B UBOX5 UBXN10 UBXN11 UBXN2B UBXN4 UBXN6 UFD1 USP7 VAMP2 VANGL2 VCF1 VCPIP1 VCPKMT WAC WRN XAF1 YWHAZ ZBTB25	318 interacting genes: AAMDC ABHD17C ADCY4 AGFG1 AIRIM AK2 AK3 ANKRD11 ANKRD45 ARFIP2 ARHGAP29 ARHGEF5 ARHGEF6 ARMC7 ATXN3 ATXN3L ATXN7 BBX BMF BSCL2 BYSL C14orf39 C1orf216 C1orf35 C1QTNF2 C2orf49 C8orf74 CALM3 CARD9 CATSPERT CAVIN2 CBX8 CCDC102B CCDC146 CCDC17 CCDC187 CCDC26 CCDC28A CCDC87 CCHCR1 CCNC CDC37 CDK18 CDKAL1 CDKN1A CENPX CEP57L1 CEP68 CFAP100 CFAP206 CFAP53 CHCHD2 CHD2 CHD3 CKM CLPP CMIP CNGA3 CRADD CSNK2B CTNNA3 CWF19L2 CYTH4 DAXX DCAF8 DCLRE1B DCUN1D1 DDX6 DEUP1 DNAL4 DNASE1L1 DPYSL4 DRC4 DRG2 DTNB DTX2 DUSP16 DVL3 DYNC2I2 DYNLL1 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPHB2 EPM2AIP1 EXOC7 EXOC8 EXOSC5 EXTL2 FAM110A FAM124A FAM124B FAM161A FAM50B FAM90A1 FAM9A FARS2 FBF1 FBXO16 FBXW2 FLNC FMNL1 G2E3 GEM GIMAP2 GLP2R GMCL1 GNG13 GNL3L GTF2I GTF2IRD2 GTF2IRD2B HAUS1 HBG1 HDAC10 HGS HMMR HOXB5 HSF2 HSPB1 HYAL2 IL18RAP IL36A IL4I1 ING3 INPP5J IQUB ITGAE ITPKB JOSD1 KANK2 KAT14 KDM1A KIF9 KIFC3 KLHL38 KLHL42 KPNA2 KRT1 KRT3 KRT4 KRT6A KRT6B KRT6C KRT75 KRT76 KRT78 KRT79 KRT8 KRTAP11-1 KRTAP9-2 LENG1 LIN37 LINC00887 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAD2L2 MAOB MAPK3 MBD3 MCM7 MEAF6 MFAP1 MGARP MICAL2 MID2 MNS1 MRTFA MSH5 MYLK2 MYO15B MYO5B NEK6 NGLY1 NTAQ1 NUP54 NUP58 OFCC1 OSGIN1 OSTF1 OTUB1 OTUB2 PABPC3 PAIP2 PARVG PCDHGB1 PCDHGC3 PCSK7 PDZK1IP1 PICK1 PIK3R3 PIWIL1 PLEKHM1 PLK4 PPIG PPP1R18 PRF1 PRKAB2 PRKG1 PRMT5 PRPF18 PRR35 PSMA1 PYGM RAB35 RABGEF1 RAD23A RAPSN RASSF10 RBM15B RBM41 RCOR3 RELT RIMS3 RNF4 RSRC2 RUNX1T1 SCNM1 SDCBP SEC14L4 SELE SEMA4C SENP3 SH2D1B SHC3 SLC13A2 SLITRK3 SMARCD1 SMARCE1 SNF8 SOX14 SPG21 SPRING1 SSX2IP STAM STRC STXBP4 STYXL1 SYCE3 SYTL5 TBC1D22B TCAF1 TCAP TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP4 THOC1 TJAP1 TLE6 TLR10 TMEM30A TNFAIP1 TNR TRIM55 TRIM63 TRIM69 TRIML2 TSG101 TSHZ3 TSPEAR TSSK3 TTC23 TTC9C TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UBL4A UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP35 USP4 USP5 USP7 USP8 UTP14C VAMP4 VCAM1 VCP VPS28 VPS9D1 XAF1 YEATS4 YOD1 ZBTB16 ZFHX3 ZGPAT ZNF180 ZNF182 ZNF250 ZNF267 ZNF366 ZNF417 ZNF572 ZNF587 ZNF667-AS1
Entrez ID		7415	57159
HPRD ID		03013	05928
Ensembl ID		ENSG00000165280	ENSG00000138100
Uniprot IDs		C9JUP7 P55072	Q9BYV2
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW 4KDI 4KDL 4KLN 4KO8 4KOD 4P0A 5B6C 5C18 5C19 5C1A 5C1B 5DYG 5DYI 5EPP 5FTJ 5FTK 5FTL 5FTM 5FTN 5GLF 5IFS 5IFW 5KIW 5KIY 5X4L 6G2V 6G2W 6G2X 6G2Y 6G2Z 6G30 6HD0 6MCK 7BP8 7BP9 7BPA 7BPB 7JY5 7K56 7K57 7K59 7L5W 7L5X 7LMY 7LMZ 7LN0 7LN1 7LN2 7LN3 7LN4 7LN5 7LN6 7MDM 7MDO 7MHS 7OAT 7PUX 7R7S 7R7T 7R7U 7RL6 7RL7 7RL9 7RLA 7RLB 7RLC 7RLD 7RLF 7RLG 7RLH 7RLI 7RLJ 7VCS 7VCT 7VCU 7VCV 7VCX 7Y4W 7Y53 7Y59 8B5R 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT 8HL7 8HRZ 8KG2 8OOI 8PQX 8R0E 8RS9 8RSB 8RSC 8UV2 8UVO 8UVP 8UVQ 8VKU 8VLS 8VOV 8YKA 9BOQ	3Q1D
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Protein Metabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process ERAD Pathway Catabolic Process Ubiquitin Binding Cellular Response To Stress Macromolecule Metabolic Process Post-translational Protein Modification ATPase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signal Transduction Protein Modification Process Cellular Response To Misfolded Protein Positive Regulation Of Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Activity Response To Stress Ubiquitin-ubiquitin Ligase Activity Intracellular Signal Transduction Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Cytosol Ubiquitin Protein Ligase Binding Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Regulation Of Protein Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Intracellular Transport Golgi Organization Nucleus Protein Polyubiquitination Postsynapse Protein Binding Negative Regulation Of Proteolysis	Cysteine-type Deubiquitinase Activity Protein Binding Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Keratin Filament Post-translational Protein Modification Ubiquitin Binding Cytosol Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Protein Modification Process Intermediate Filament-based Process Protein K48-linked Deubiquitination Keratinization Organelle Organization Cytoplasm Intermediate Filament Ubiquitin Conjugating Enzyme Activity Centrosome Positive Regulation Of Exosomal Secretion Deubiquitinase Activity Cytoskeleton Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway K48-linked Deubiquitinase Activity Ubiquitin-dependent Protein Catabolic Process Membrane Fission Regulation Of Exosomal Secretion Modification-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of TORC1 Signaling Regulation Of DNA Repair Peptidase Activity Nucleus Proteolysis Microtubule-based Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Regulation Of Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Double-strand Break Repair Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Extracellular Exosome Assembly DeNEDDylase Activity Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Cytoskeleton Microtubule-based Movement Endosome Organization
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