VCP and ASPSCR1

Number of citations of the paper that reports this interaction (PMID 23383273)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		VCP	ASPSCR1
Gene Name		valosin containing protein	alveolar soft part sarcoma chromosome region, candidate 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cellular_component Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endomembrane System Vesicle Membrane Extrinsic Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding	Molecular_function Protein Binding
	Biological Process	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity	Intracellular Protein Transport Biological_process Glucose Homeostasis Regulation Of Glucose Import Membrane Organization
Pathways		HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B	11 interactors: ADAMTSL4 APP KRT31 KRTAP10-8 NEDD4 NOTCH2NL PHAX TACC3 TCF4 VCP VCPKMT
Entrez ID		7415	79058
HPRD ID		03013	06947
Ensembl ID		ENSG00000165280	ENSG00000169696
Uniprot IDs		P55072 Q96IF9	Q9BZE9
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling	Regulation Of Nucleocytoplasmic Transport Cytoplasmic Transport Cellular Localization Intracellular Transport Neuromuscular Junction Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Transmission Of Virus Development Involved In Symbiotic Interaction Protein Localization Regulation Of Intracellular Transport Regulation Of Synapse Structure Or Activity Forebrain Development Response To Abiotic Stimulus Establishment Of Localization In Cell SnRNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Metabolic Process Regulation Of Neuron Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Collateral Sprouting In Absence Of Injury Notch Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Maintenance Of DNA Repeat Elements Cellular Protein Localization Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Positive Regulation Of Cell Death Protein Transport Collateral Sprouting Axon Midline Choice Point Recognition Retrograde Protein Transport, ER To Cytosol Establishment Of Protein Localization Synapse Organization Regulation Of Protein Deubiquitination Progesterone Receptor Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Hindgut Morphogenesis Astral Microtubule Organization Regulation Of Neurogenesis Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Genitalia Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Tagcloud ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	17p 1p36 1q 1q13 1q21 4q21 7p 7q 8p 8q 8q11 9p cirrhotic etv1and ffpe fgfr3 gains hcc hccs maf nearby pathologically pter q23 q26 recql4 stac xp xq
Tagcloud (Difference) ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	17p 1p36 1q 1q13 1q21 4q21 7p 7q 8p 8q 8q11 9p cirrhotic etv1and ffpe fgfr3 gains hcc hccs maf nearby pathologically pter q23 q26 recql4 stac xp xq
Tagcloud (Intersection) ?