VCP and XAF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VCP	XAF1
Description		valosin containing protein	XIAP associated factor 1
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GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Cytoplasmic Stress Granule Protein-containing Complex VCP-NPL4-UFD1 AAA ATPase Complex Secretory Granule Lumen Azurophil Granule Lumen Site Of Double-strand Break Ciliary Basal Body Derlin-1 Retrotranslocation Complex Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Ficolin-1-rich Granule Lumen ATPase Complex VCP-NSFL1C Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Lipid Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity K48-linked Polyubiquitin Modification-dependent Protein Binding MHC Class I Protein Binding Identical Protein Binding ADP Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Sequestering Activity
	Biological Process	DNA Repair Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy DNA Damage Response Canonical NF-kappaB Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Potential Macroautophagy Protein Ubiquitination Viral Genome Replication NAD+ Metabolic Process Translesion Synthesis Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cellular Response To Heat Negative Regulation Of Hippo Signaling Stress Granule Disassembly Interstrand Cross-link Repair ERAD Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway ATP Metabolic Process Regulation Of Synapse Organization Mitotic Spindle Disassembly Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Aggresome Assembly Cellular Response To Misfolded Protein Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Autophagosome Maturation Protein-DNA Covalent Cross-linking Repair Negative Regulation Of Protein Localization To Chromatin Cytoplasm Protein Quality Control Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Cellular Response To Arsenite Ion Positive Regulation Of Oxidative Phosphorylation Regulation Of Protein Localization To Chromatin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Interferon-beta
Pathways		Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation Neddylation RHOH GTPase cycle Aggrephagy Attachment and Entry Attachment and Entry KEAP1-NFE2L2 pathway AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Interferon alpha/beta signaling
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Phenethyl Isothiocyanate
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		98 interacting genes: ABHD17C AMFR ANKRD13A AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BAG5 BRCA1 BRSK2 BUD23 CACNA1C CEP19 CLUAP1 CRMP1 CSTF1 DERL1 DGCR6 DTNB ELAVL1 EPHB4 EPSTI1 ESR1 GZMK HDAC6 HTT INSIG1 INSIG2 JAK2 LINC01554 LNX1 LZIC MAPK8IP2 MDM2 METTL17 NDRG1 NF1 NFKBIA NGLY1 NOD2 NSFL1C NTAQ1 NUB1 OPTN PBK PIK3R3 PLAA PPP1CC PPP1R11 PPP1R3A PPP1R7 PRKCD PSMA1 PSMC1 PTPN3 RIPK4 RNF10 RNF115 RNF19A RNF8 RPS6KA1 SELENOS SH2D2A SLC43A3 SNCA SPRTN STUB1 STX5 SUMO4 SVIP TMUB1 TOM1L1 TOMM34 TRIM54 UBASH3A UBC UBE4A UBE4B UBOX5 UBXN10 UBXN11 UBXN2B UBXN4 UBXN6 UFD1 USP7 VAMP2 VANGL2 VCF1 VCPIP1 VCPKMT WAC WRN XAF1 YWHAZ ZBTB25	20 interacting genes: AKT1 APP BIRC7 BRCA1 CREBBP ESR1 GLS2 HSPA5 LRSAM1 RFC5 RNF166 SEPHS1 TP53 TRIM21 TRIM50 TRIM54 TRIML2 UBXN2B VCP XIAP
Entrez ID		7415	54739
HPRD ID		03013	06978
Ensembl ID		ENSG00000165280	ENSG00000132530
Uniprot IDs		C9JUP7 P55072	Q6GPH4
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW 4KDI 4KDL 4KLN 4KO8 4KOD 4P0A 5B6C 5C18 5C19 5C1A 5C1B 5DYG 5DYI 5EPP 5FTJ 5FTK 5FTL 5FTM 5FTN 5GLF 5IFS 5IFW 5KIW 5KIY 5X4L 6G2V 6G2W 6G2X 6G2Y 6G2Z 6G30 6HD0 6MCK 7BP8 7BP9 7BPA 7BPB 7JY5 7K56 7K57 7K59 7L5W 7L5X 7LMY 7LMZ 7LN0 7LN1 7LN2 7LN3 7LN4 7LN5 7LN6 7MDM 7MDO 7MHS 7OAT 7PUX 7R7S 7R7T 7R7U 7RL6 7RL7 7RL9 7RLA 7RLB 7RLC 7RLD 7RLF 7RLG 7RLH 7RLI 7RLJ 7VCS 7VCT 7VCU 7VCV 7VCX 7Y4W 7Y53 7Y59 8B5R 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT 8HL7 8HRZ 8KG2 8OOI 8PQX 8R0E 8RS9 8RSB 8RSC 8UV2 8UVO 8UVP 8UVQ 8VKU 8VLS 8VOV 8YKA 9BOQ	2LXW
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Protein Metabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process ERAD Pathway Catabolic Process Ubiquitin Binding Cellular Response To Stress Macromolecule Metabolic Process Post-translational Protein Modification ATPase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signal Transduction Protein Modification Process Cellular Response To Misfolded Protein Positive Regulation Of Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Activity Response To Stress Ubiquitin-ubiquitin Ligase Activity Intracellular Signal Transduction Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Cytosol Ubiquitin Protein Ligase Binding Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Regulation Of Protein Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Intracellular Transport Golgi Organization Nucleus Protein Polyubiquitination Postsynapse Protein Binding Negative Regulation Of Proteolysis	Ubiquitin Protein Ligase Activity Protein Ubiquitination Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Metabolic Process Macromolecule Metabolic Process Zinc Ion Binding Regulation Of Post-translational Protein Modification Protein Modification Process Response To Stress Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Transferase Activity Identical Protein Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intracellular Signaling Cassette Protein K6-linked Ubiquitination Metal Ion Binding 14-3-3 Protein Binding Cytoplasm Proteolysis Involved In Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-protein Transferase Activity ER-nucleus Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Macromolecule Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Protein-containing Complex Positive Regulation Of Nitric Oxide Metabolic Process Immune System Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Cycle Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Defense Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transcription Coactivator Binding Stress Granule Disassembly Cellular Response To Stress Regulation Of Small Molecule Metabolic Process Negative Regulation Of Apoptotic Process
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