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VCP and LNX1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
VCP
LNX1
Gene Name
valosin containing protein
ligand of numb-protein X 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Hrd1p Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Particle
Cytosol
Site Of Double-strand Break
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Cytoplasm
Molecular Function
Receptor Binding
Protein Binding
ATP Binding
Lipid Binding
ATPase Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Polyubiquitin Binding
Protein Complex Binding
Deubiquitinase Activator Activity
Identical Protein Binding
ADP Binding
Poly(A) RNA Binding
Ubiquitin-specific Protease Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
PDZ Domain Binding
Biological Process
DNA Repair
Double-strand Break Repair
ER To Golgi Vesicle-mediated Transport
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein N-linked Glycosylation Via Asparagine
Translesion Synthesis
ER-associated Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Hexamerization
Cellular Response To Heat
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Establishment Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Protein Homooligomerization
Aggresome Assembly
Positive Regulation Of Protein K63-linked Deubiquitination
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Homooligomerization
Pathways
HSF1 activation
Hedgehog ligand biogenesis
Processing-defective Hh variants abrogate ligand secretion
Hh ligand biogenesis disease
Signaling by Hedgehog
Cellular response to heat stress
Drugs
Diseases
GWAS
DNA methylation (variation) (
23725790
)
Protein-Protein Interactions
72 interactors:
AMFR
AR
ASPSCR1
ATG5
ATXN1
ATXN3
ATXN7
BRCA1
BRSK2
CAV1
CEP19
CRMP1
DERL1
DGCR6
DTNB
FAM104A
GZMK
HDAC6
HERPUD1
HTT
INSIG1
INSIG2
JAK2
LNX1
MAPK8IP2
NDRG1
NF1
NFKBIA
NGLY1
NPLOC4
NSFL1C
NUB1
OTULIN
PLAA
PRKCD
PSMA1
PSMA7
PSMC1
PTPN3
RNF19A
RNF31
RNF8
RPL9
RPS6KA1
SH2D2A
SIK2
STUB1
STX5
SUMO4
SVIP
SYVN1
TOM1L1
TOMM34
UBE4A
UBE4B
UBOX5
UBQLN1
UBXN1
UBXN2A
UBXN2B
UBXN6
UFD1L
VCPIP1
VCPKMT
VIMP
WAC
WBSCR22
WDYHV1
WRN
YOD1
YWHAZ
ZFAND2B
218 interactors:
ABCA1
ABCB1
ABR
ACAT2
ACY3
ADRA1D
AGTRAP
AIDA
AIMP2
AKIRIN2
ALDOC
ALKBH3
AMMECR1L
APIP
APOL4
APP
ARHGAP6
ARHGEF16
ARVCF
ATPAF2
ATRIP
AURKC
BCR
BLVRA
BPIFA1
C1QTNF1
CA8
CALCOCO2
CAMK2N2
CATSPERD
CCDC101
CCDC102B
CCDC114
CCDC85B
CDA
CDC42EP4
CEP72
CGN
CIB3
CIRBP
CITED1
CLDN1
CLDN17
CLDN2
CLK2
COIL
CPNE2
CTBP1
CTNND2
CTSO
CUTC
CXADR
DAB1
DAPK1
DCTD
DCUN1D5
DDX17
DEPTOR
DNPEP
DOCK9
DPF2
DVL3
EBF4
EHMT2
EIF4H
ENOX1
EPHB3
EXOC8
FAM118A
FAM124A
FAM212B
FAM9B
FBP1
FBXL12
FHL3
GAS2L2
GDI1
GIPR
GJD4
GOLPH3L
GPR142
GRB2
GRIN1
HMBOX1
HOMEZ
HSBP1
HTR2B
HUNK
IGSF5
IL3RA
ILF3
INSC
ISCU
JOSD1
KALRN
KCNA4
KCTD1
KCTD13
KCTD17
KCTD6
KHDRBS3
KIAA1598
KLHL12
KRT15
KRTAP4-12
KRTAP4-2
KRTAP9-2
KXD1
LCLAT1
LDOC1
LGALS14
LGR6
LNX2
LRRC3B
LSM2
MAGEA11
MAGEB18
MAPK9
MEMO1
METTL21A
MRFAP1L1
MRPS24
MTMR9
MTUS2
MUSTN1
MVB12B
NADK
NAGK
NCK2
NECAB2
NEK6
NKD2
NME7
NOTCH2NL
NRCAM
NUDT14
NUMB
NUP37
NXT2
ORMDL3
OSBP2
OSGIN1
PAFAH1B3
PAICS
PBK
PBLD
PCBD1
PDZRN3
PDZRN4
PKDREJ
PKM
PKP4
POMGNT1
PPIA
PPID
PQBP1
PRR13
PTGIR
PTS
RABAC1
RAD51D
RAD54B
RBMX
RBMY1A1
RFPL3
ROBO3
ROPN1
RPIA
RUFY4
RUVBL2
SAPCD1
SAT1
SCLT1
SDK1
SLC6A15
SLC6A5
SNCB
SNRNP25
SNRPF
SPHKAP
SRSF1
SSNA1
SSTR3
STAC2
STRN
STX5
SUV39H1
SUV39H2
TBCEL
THAP7
TIFA
TMEM14C
TNFRSF18
TPM4
TRAF2
TRIM23
TRIM39
TRIM54
TRIP13
TRMT12
TSC2
TSC22D4
TSSK3
TYRO3
UBE2D2
ULK2
VCP
VRK2
WAC
WNT8A
WWP1
ZADH2
ZBTB43
ZBTB8A
ZCCHC10
ZFP64
ZNF581
ZNF593
Entrez ID
7415
84708
HPRD ID
03013
17287
Ensembl ID
ENSG00000165280
ENSG00000072201
Uniprot IDs
P55072
Q96IF9
Q8TBB1
PDB IDs
3EBB
3HU1
3HU2
3HU3
3QC8
3QQ7
3QQ8
3QWZ
3TIW
3B76
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Response To Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Metabolic Process
Proteolysis
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Response To Stress
Catabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Cellular Metabolic Process
Regulation Of Protein Ubiquitination
Cellular Protein Modification Process
Cellular Response To Topologically Incorrect Protein
ER-nucleus Signaling Pathway
Golgi Organization
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cell Communication
Regulation Of Protein Catabolic Process
Response To Endoplasmic Reticulum Stress
ER-associated Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stimulus
Negative Regulation Of Apoptotic Process
Regulation Of Proteolysis
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Death
Negative Regulation Of Cellular Protein Metabolic Process
Apoptotic Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Metabolic Process
Negative Regulation Of Cell Death
Positive Regulation Of Cellular Metabolic Process
Regulation Of Apoptotic Process
Cellular Response To Unfolded Protein
Programmed Cell Death
Negative Regulation Of Protein Metabolic Process
Cell Death
Death
Negative Regulation Of Signal Transduction
Response To Stimulus
Response To Unfolded Protein
Negative Regulation Of Signaling
Cellular Component Assembly
Protein Homooligomerization
Protein Oligomerization
Protein Complex Assembly
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cellular Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Regulation Of Cellular Component Organization
Cellular Aromatic Compound Metabolic Process
Regulation Of Rho Protein Signal Transduction
Response To Stimulus
Developmental Process
Cellular Metabolic Process
Peptidyl-lysine Dimethylation
Heterocycle Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Neutrophil Degranulation
Cellular Response To Stimulus
Viral Process
Programmed Cell Death
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Splicing
Cellular Nitrogen Compound Metabolic Process
Protein Tetramerization
Cell Death
Apoptotic Process
Death
Neuron Recognition
Cell Communication
Signaling
Regulation Of Neutrophil Degranulation
Negative Regulation Of Neutrophil Activation
Viral Release From Host Cell
Regulation Of Rho GTPase Activity
Cell-cell Junction Organization
Protein Autophosphorylation
Response To Abiotic Stimulus
Organelle Organization
Regulation Of Cell Morphogenesis
Nitrogen Compound Metabolic Process
Axon Midline Choice Point Recognition
Positive Regulation Of Rho GTPase Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Homodimerization Activity
Regulation Of Ras Protein Signal Transduction
Protein Heterooligomerization
Biosynthetic Process
Tagcloud
?
17q11
3q28
9pter
ap2
ap50
aps
blots
clapb1
clapm1
clathrin
coated
denoted
designated
dnas
endocytosis
lattice
locations
mapped
maps
oligonucleotide
porcine
primers
probe
q12
q34
rodent
served
stoichiometric
triskelia
Tagcloud (Difference)
?
17q11
3q28
9pter
ap2
ap50
aps
blots
clapb1
clapm1
clathrin
coated
denoted
designated
dnas
endocytosis
lattice
locations
mapped
maps
oligonucleotide
porcine
primers
probe
q12
q34
rodent
served
stoichiometric
triskelia
Tagcloud (Intersection)
?