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VCP and PSMA1
Number of citations of the paper that reports this interaction (PubMedID
35831314
)
73
Data Source:
BioGRID
(two hybrid, two hybrid, biochemical, affinity chromatography technology)
VCP
PSMA1
Description
valosin containing protein
proteasome 20S subunit alpha 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytosol
Cytoplasmic Stress Granule
Protein-containing Complex
VCP-NPL4-UFD1 AAA ATPase Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Site Of Double-strand Break
Ciliary Basal Body
Derlin-1 Retrotranslocation Complex
Intracellular Membrane-bounded Organelle
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Ficolin-1-rich Granule Lumen
ATPase Complex
VCP-NSFL1C Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Molecular Function
Nucleotide Binding
RNA Binding
Protein Binding
ATP Binding
Lipid Binding
Hydrolase Activity
ATP Hydrolysis Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Deubiquitinase Activator Activity
K48-linked Polyubiquitin Modification-dependent Protein Binding
MHC Class I Protein Binding
Identical Protein Binding
ADP Binding
Ubiquitin-like Protein Ligase Binding
Protein-containing Complex Binding
Ubiquitin-modified Protein Reader Activity
BAT3 Complex Binding
Ubiquitin-specific Protease Binding
Lipopolysaccharide Binding
Protein Binding
Biological Process
DNA Repair
Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Autophagy
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Proteasomal Protein Catabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Macroautophagy
Protein Ubiquitination
Viral Genome Replication
NAD+ Metabolic Process
Translesion Synthesis
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
Cellular Response To Heat
Negative Regulation Of Hippo Signaling
Stress Granule Disassembly
Interstrand Cross-link Repair
ERAD Pathway
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Establishment Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Smoothened Signaling Pathway
ATP Metabolic Process
Regulation Of Synapse Organization
Mitotic Spindle Disassembly
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Aggresome Assembly
Cellular Response To Misfolded Protein
Flavin Adenine Dinucleotide Catabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Autophagosome Maturation
Protein-DNA Covalent Cross-linking Repair
Negative Regulation Of Protein Localization To Chromatin
Cytoplasm Protein Quality Control
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein K63-linked Deubiquitination
Regulation Of Aerobic Respiration
Cellular Response To Arsenite Ion
Positive Regulation Of Oxidative Phosphorylation
Regulation Of Protein Localization To Chromatin
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of ATP Biosynthetic Process
Immune System Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Pathways
Translesion Synthesis by POLH
HSF1 activation
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Defective CFTR causes cystic fibrosis
Josephin domain DUBs
Ovarian tumor domain proteases
Neutrophil degranulation
E3 ubiquitin ligases ubiquitinate target proteins
Protein methylation
Neddylation
RHOH GTPase cycle
Aggrephagy
Attachment and Entry
Attachment and Entry
KEAP1-NFE2L2 pathway
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Phenethyl Isothiocyanate
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Response to quetiapine in schizophrenia (
29503163
)
Alzheimer's disease (cognitive decline) (
23535033
)
Bipolar disorder (
31043756
)
Diastolic blood pressure (
27841878
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
HDL cholesterol levels (
32203549
)
High chromosomal aberration frequency (total) (
31586183
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Skin and soft tissue infections (
33662382
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32154731
32203549
)
Vitamin D levels (
25208829
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
98 interacting genes:
ABHD17C
AMFR
ANKRD13A
AR
ASPSCR1
ATG5
ATXN1
ATXN3
ATXN7
BAG5
BRCA1
BRSK2
BUD23
CACNA1C
CEP19
CLUAP1
CRMP1
CSTF1
DERL1
DGCR6
DTNB
ELAVL1
EPHB4
EPSTI1
ESR1
GZMK
HDAC6
HTT
INSIG1
INSIG2
JAK2
LINC01554
LNX1
LZIC
MAPK8IP2
MDM2
METTL17
NDRG1
NF1
NFKBIA
NGLY1
NOD2
NSFL1C
NTAQ1
NUB1
OPTN
PBK
PIK3R3
PLAA
PPP1CC
PPP1R11
PPP1R3A
PPP1R7
PRKCD
PSMA1
PSMC1
PTPN3
RIPK4
RNF10
RNF115
RNF19A
RNF8
RPS6KA1
SELENOS
SH2D2A
SLC43A3
SNCA
SPRTN
STUB1
STX5
SUMO4
SVIP
TMUB1
TOM1L1
TOMM34
TRIM54
UBASH3A
UBC
UBE4A
UBE4B
UBOX5
UBXN10
UBXN11
UBXN2B
UBXN4
UBXN6
UFD1
USP7
VAMP2
VANGL2
VCF1
VCPIP1
VCPKMT
WAC
WRN
XAF1
YWHAZ
ZBTB25
173 interacting genes:
ABCD3
ABI2
ABI3
ACTN1
ACTN2
AGR2
APIP
APP
BANF2
BLZF1
C22orf39
CABP5
CALCOCO2
CBS
CCDC102B
CCDC136
CCDC85B
CCNH
CDA
CDKN2D
CDR2
CEBPA
CEP70
CEP72
CFAP206
CHMP1A
CINP
CIP2A
COG4
COG6
COIL
CRX
CSTPP1
DCTD
DCTPP1
DDIT4L
DEF6
DLEU1
DRC12
DYDC1
DYNLT1
EHMT2
EIF4A3
EMSY
ERBB2
FNDC11
GNPTAB
GOLGA2
GOLGA6A
GPHN
GSDMD
GUCD1
HEXIM2
HOMER3
HOMEZ
HOOK2
HOXC11
HSD17B14
HSF2BP
IFT20
IKZF1
IKZF3
INO80E
IPO13
KAZN
KCTD1
KCTD13
KCTD17
KCTD6
KCTD7
KCTD9
KHDRBS3
KRT13
KRT15
KRT19
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP1-1
KRTAP1-3
KRTAP4-1
KRTAP5-9
KRTAP6-3
LDB1
LDOC1
LINC00632
LMO2
LONRF1
LZTFL1
LZTS1
LZTS2
MAD1L1
MAPK1
MAPRE1
MAPRE3
MCM6
MDH2
MID2
MIEF1
MKNK2
MKRN3
MLH1
MRFAP1L1
MSANTD4
MT-CO2
MTUS2
NAB2
NBPF19
NECAB2
NME7
NMI
NOP53
NOTCH2NLA
PCBD1
PCYT2
PICK1
PLK1
PM20D2
PNMA1
PNMA2
PNMA5
POLR1C
PPCDC
PRDM14
PRIMPOL
PRKN
PRPH
PSMA2
PSMA3
PSMA4
PSMA7
PSMB10
PSMB2
PSMB5
RAD54B
RBCK1
REL
RFC2
RGS19
ROPN1
SAT1
SFMBT1
SH3BP4
SH3GLB1
SLF2
SNCA
SPDEF
SSX2IP
TCF12
TCF4
TDO2
TEKT4
TNFAIP1
TNR
TRAF1
TRAF5
TRIM10
TRIM23
TRIM27
TRIM42
TRIM54
TSC22D4
UBD
UBXN11
VCP
VIM
VMAC
WTAP
YPEL5
ZFAND1
ZMYND19
Entrez ID
7415
5682
HPRD ID
03013
04170
Ensembl ID
ENSG00000165280
ENSG00000129084
Uniprot IDs
C9JUP7
P55072
B4E0X6
P25786
PDB IDs
3EBB
3HU1
3HU2
3HU3
3QC8
3QQ7
3QQ8
3QWZ
3TIW
4KDI
4KDL
4KLN
4KO8
4KOD
4P0A
5B6C
5C18
5C19
5C1A
5C1B
5DYG
5DYI
5EPP
5FTJ
5FTK
5FTL
5FTM
5FTN
5GLF
5IFS
5IFW
5KIW
5KIY
5X4L
6G2V
6G2W
6G2X
6G2Y
6G2Z
6G30
6HD0
6MCK
7BP8
7BP9
7BPA
7BPB
7JY5
7K56
7K57
7K59
7L5W
7L5X
7LMY
7LMZ
7LN0
7LN1
7LN2
7LN3
7LN4
7LN5
7LN6
7MDM
7MDO
7MHS
7OAT
7PUX
7R7S
7R7T
7R7U
7RL6
7RL7
7RL9
7RLA
7RLB
7RLC
7RLD
7RLF
7RLG
7RLH
7RLI
7RLJ
7VCS
7VCT
7VCU
7VCV
7VCX
7Y4W
7Y53
7Y59
8B5R
8FCL
8FCM
8FCN
8FCO
8FCP
8FCQ
8FCR
8FCT
8HL7
8HRZ
8KG2
8OOI
8PQX
8R0E
8RS9
8RSB
8RSC
8UV2
8UVO
8UVP
8UVQ
8VKU
8VLS
8VOV
8YKA
9BOQ
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
Enriched GO Terms of Interacting Partners
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Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
ERAD Pathway
Catabolic Process
Ubiquitin Binding
Cellular Response To Stress
Macromolecule Metabolic Process
Post-translational Protein Modification
ATPase Binding
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Negative Regulation Of Signal Transduction
Protein Modification Process
Cellular Response To Misfolded Protein
Positive Regulation Of Catabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Response To Misfolded Protein
Response To Endoplasmic Reticulum Stress
Cellular Response To Topologically Incorrect Protein
Ubiquitin Protein Ligase Activity
Response To Stress
Ubiquitin-ubiquitin Ligase Activity
Intracellular Signal Transduction
Cytoplasm
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Autophagy
Cytosol
Ubiquitin Protein Ligase Binding
Regulation Of Intracellular Protein Transport
Regulation Of Protein Localization
Regulation Of Protein Catabolic Process
Ubiquitin-protein Transferase Activity
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Response To Stress
Regulation Of Intracellular Transport
Golgi Organization
Nucleus
Protein Polyubiquitination
Postsynapse
Protein Binding
Negative Regulation Of Proteolysis
Identical Protein Binding
Protein Binding
Cytoskeleton
Intermediate Filament
Proteasome Core Complex
Keratin Filament
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Cytoplasm
Supramolecular Fiber Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Organelle Organization
Proteasome Complex
Cytosol
Protein Homooligomerization
Proteasome Core Complex, Alpha-subunit Complex
Protein Complex Oligomerization
Cytoskeleton Organization
Protein Domain Specific Binding
Aggresome Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Serine/threonine Kinase Binding
Regulation Of Microtubule-based Process
Inclusion Body Assembly
Cytosine Metabolic Process
Structural Molecule Activity
Positive Regulation Of Protein K63-linked Deubiquitination
Cullin Family Protein Binding
Nucleus
Proteasome Core Complex, Beta-subunit Complex
Microtubule-based Process
Positive Regulation Of Organelle Organization
Ficolin-1-rich Granule Lumen
Regulation Of Microtubule Cytoskeleton Organization
Type III Intermediate Filament
Cellular Response To Arsenite Ion
Lung Goblet Cell Differentiation
Mitotic Spindle Astral Microtubule End
Protein Localization To Microtubule
Centrosome
Proteasomal Protein Catabolic Process
Cellular Component Assembly
Glial Cell Development
Mitotic Spindle Pole
Proteolysis Involved In Protein Catabolic Process
Pseudopodium
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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