NDRG1 and S100B

Number of citations of the paper that reports this interaction (PMID 12493777)
21

Data Source:
HPRD (in vitro, in vivo)

		NDRG1	S100B
Gene Name		N-myc downstream regulated 1	S100 calcium binding protein B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Lymphocyte counts ( 22286170)
Protein-Protein Interactions		64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		10397	6285
HPRD ID		05586	01505
Ensembl ID		ENSG00000104419
Uniprot IDs		Q8N959 Q92597	P04271
PDB IDs			1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?