NDRG1 and TAF9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NDRG1	TAF9
Description		N-myc downstream regulated 1	TATA-box binding protein associated factor 9
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	Transcription Cis-regulatory Region Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding DNA-binding Transcription Factor Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Box C/D SnoRNP Assembly Regulation Of DNA Repair Chromatin Remodeling DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155	57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		10397	6880
HPRD ID		05586	15983
Ensembl ID		ENSG00000104419	ENSG00000273841
Uniprot IDs		Q8N959 Q92597	Q16594
PDB IDs		6ZMM	6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8H7G 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIID Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter RNA Polymerase II Preinitiation Complex Assembly Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process TBP-class Protein Binding Protein-DNA Complex Assembly MLL1 Complex Nucleic Acid Metabolic Process Transcription Factor TFTC Complex Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Repair
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