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NDRG1 and HSPA5
Number of citations of the paper that reports this interaction (PubMedID
17220478
)
0
Data Source:
HPRD
(in vivo)
NDRG1
HSPA5
Description
N-myc downstream regulated 1
heat shock protein family A (Hsp70) member 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Adherens Junction
Microtubule Cytoskeleton
Membrane
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Extracellular Exosome
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Binding
Microtubule Binding
Nickel Cation Binding
Small GTPase Binding
Gamma-tubulin Binding
Cadherin Binding
Nucleotide Binding
Calcium Ion Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
Protein Domain Specific Binding
Protein Serine/threonine Kinase Inhibitor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Misfolded Protein Binding
ATP-dependent Protein Folding Chaperone
Biological Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Response To Metal Ion
DNA Damage Response, Signal Transduction By P53 Class Mediator
Peripheral Nervous System Myelin Maintenance
Mast Cell Activation
Cellular Response To Hypoxia
Translational Initiation
Protein Folding
ER Overload Response
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Post-translational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Maintenance Of Protein Localization In Endoplasmic Reticulum
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ERAD Pathway
Protein Refolding
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Interleukin-4
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
ATF6B (ATF6-beta) activates chaperones
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Modulation of host responses by IFN-stimulated genes
Drugs
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Estimated glomerular filtration rate (
31015462
)
Left-handedness (
32989287
)
Nontyphoidal Salmonella bacteraemia (
29523850
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Refractive error (
32231278
)
Smoking initiation (
33082346
)
Interacting Genes
71 interacting genes:
ACSL3
ACTG1
AP1M2
AP2M1
APOA1
APOA2
ARL4D
ATP1A1
CANX
CDH1
CLTC
CNDP2
COPB2
CTNNB1
DDX1
DDX5
DLST
EEF1G
EEF2
EIF2S3
EIF3E
ETS2
EWSR1
FASN
GSK3B
HNRNPF
HNRNPH1
HNRNPU
HSD17B4
HSP90AA1
HSPA5
ILF3
KIF5B
LDHA
MAOA
MLH1
MME
MYC
NCL
NR4A1
PABPC1
PHYHIP
PKM
PPP2R2A
PRKACA
PSMC2
PSMC3
PSMD2
RPL24
RPL3
RPL4
RPN2
RPS16
RPS20
RPS26
RPS3
RPS6
RPS8
RTN1
RUVBL2
S100B
SEC23A
SGK1
SHMT2
TAF9
TARS1
TLE3
UPF1
VCP
XRCC5
ZNF155
77 interacting genes:
A2M
AGO4
APC
APOB
BAG3
BCAR1
CASP7
CDK7
CPT1A
DDX24
DNAJC1
DNAJC10
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
FNDC3B
GRIA1
HLA-C
HMGB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
NEDD4L
NRIP1
OTUD3
PARK7
PAWR
PCSK7
PRDM14
PRNP
PSME3
PTPN11
PTPRF
RIPK4
RNF114
RNF26
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
XAF1
YWHAB
Entrez ID
10397
3309
HPRD ID
05586
00682
Ensembl ID
ENSG00000104419
ENSG00000044574
Uniprot IDs
Q8N959
Q92597
P11021
V9HWB4
PDB IDs
6ZMM
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
6ZMD
7N1R
Enriched GO Terms of Interacting Partners
?
Ribonucleoprotein Complex
Extracellular Exosome
Cytosol
RNA Binding
Macromolecule Metabolic Process
Translation
Cytosolic Ribosome
Macromolecule Biosynthetic Process
Cadherin Binding
Response To Cytokine
Protein Metabolic Process
Response To Peptide
Secretory Granule Lumen
Cellular Response To Cytokine Stimulus
Cytoplasmic Translation
Membrane
Nucleoplasm
ATP Hydrolysis Activity
Regulation Of Protein Metabolic Process
Ribosome
Nucleobase-containing Compound Metabolic Process
Cytosolic Small Ribosomal Subunit
Structural Constituent Of Ribosome
Regulation Of Primary Metabolic Process
Small Ribosomal Subunit
Nucleotide Binding
Protein-RNA Complex Assembly
Regulation Of Translation
ATP Binding
Nucleic Acid Metabolic Process
Regulation Of Telomere Maintenance
Protein Binding
Catabolic Process
RNA Metabolic Process
Positive Regulation Of Cytoplasmic Translation
Ficolin-1-rich Granule Lumen
Protein-containing Complex Organization
Regulation Of RNA Splicing
Macromolecule Catabolic Process
Cytoplasm
Focal Adhesion
Positive Regulation Of Biosynthetic Process
Nucleus
Plasma Lipoprotein Particle Assembly
Protein-lipid Complex Assembly
Disordered Domain Specific Binding
Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Regulation Of Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Macromolecule Catabolic Process
Regulation Of Protein Localization
Endoplasmic Reticulum
Protein Metabolic Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Catabolic Process
Catabolic Process
Protein-folding Chaperone Binding
Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Autophagy
Negative Regulation Of Establishment Of Protein Localization
Adenyl-nucleotide Exchange Factor Activity
Cotranslational Protein Targeting To Membrane
Molecular Sequestering Activity
Proteolysis
Protein Modification Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Melatonin Receptor Activity
Regulation Of Metabolic Process
Negative Regulation Of Transport
Response To Stress
Regulation Of Protein Transport
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Signal Transduction
Signal Transduction
Immunoglobulin Binding
Cupric Ion Binding
Negative Regulation Of Protein Transport
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Leukocyte Activation
Scaffold Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Proteolysis
Protein Folding
Positive Regulation Of Transcription By RNA Polymerase I
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Cholesterol Storage
Negative Regulation Of T Cell Activation
Ubiquitin-like Protein Conjugating Enzyme Binding
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Tagcloud (Difference)
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Tagcloud (Intersection)
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