NDRG1 and ACSL3

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		NDRG1	ACSL3
Gene Name		N-myc downstream regulated 1	acyl-CoA synthetase long-chain family member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome	Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Particle Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint	Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Brain Development Response To Nutrient Response To Organic Cyclic Compound Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Golgi To Plasma Membrane Protein Transport Long-chain Fatty Acid Import Positive Regulation Of Secretion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways			Fatty Acyl-CoA Biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Triglyceride Biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs			Icosapent
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155	2 interactors: APP NDRG1
Entrez ID		10397	2181
HPRD ID		05586	03845
Ensembl ID		ENSG00000104419
Uniprot IDs		Q8N959 Q92597	B3KMA6 O95573
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Neuron Remodeling Positive Regulation Of Cell Cycle Checkpoint Cell Activation Cellular Copper Ion Homeostasis Regulation Of Cell Cycle Peripheral Nervous System Myelin Maintenance Copper Ion Homeostasis Suckling Behavior Regulation Of Spindle Checkpoint Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Abiotic Stimulus Myelin Maintenance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mast Cell Activation Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Regulation Of Cell Cycle Checkpoint Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Myelination In Peripheral Nervous System Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Schwann Cell Development Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Neurogenesis Schwann Cell Differentiation Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death
Tagcloud ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	1n9c agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	1n9c agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?