NDRG1 and MAOA

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		NDRG1	MAOA
Gene Name		N-myc downstream regulated 1	monoamine oxidase A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding	Primary Amine Oxidase Activity
	Biological Process	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint	Cellular Biogenic Amine Metabolic Process Xenobiotic Metabolic Process Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Dopamine clearance from the synaptic cleft Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Neurotransmitter Release Cycle Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Serotonin clearance from the synaptic cleft Amine Oxidase reactions Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Metabolism of serotonin Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Norepinephrine Neurotransmitter Release Cycle Enzymatic degradation of dopamine by COMT Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Enzymatic degradation of Dopamine by monoamine oxidase Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Neurotransmitter Clearance In The Synaptic Cleft Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Transmission across Chemical Synapses
Drugs			Phentermine Tranylcypromine Phenelzine Minaprine Zonisamide Selegiline Moclobemide Isocarboxazid Ephedra MMDA 4-Methoxyamphetamine Methamphetamine Pargyline Flavin-Adenine Dinucleotide N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine Nialamide Nomifensine Zimelidine DECYL(DIMETHYL)PHOSPHINE OXIDE 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Smoking behavior ( 19247474)
Protein-Protein Interactions		64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155	1 interactors: NDRG1
Entrez ID		10397	4128
HPRD ID		05586	02400
Ensembl ID		ENSG00000104419
Uniprot IDs		Q8N959 Q92597	P21397 Q49A63 Q53YE7
PDB IDs			1H8Q 2BXR 2BXS 2Z5X 2Z5Y
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Positive Regulation Of Spindle Checkpoint Positive Regulation Of Cell Cycle Checkpoint Peripheral Nervous System Myelin Maintenance Regulation Of Spindle Checkpoint Myelin Maintenance Mast Cell Activation Regulation Of Cell Cycle Checkpoint Myelination In Peripheral Nervous System Schwann Cell Development Schwann Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Glial Cell Development Peripheral Nervous System Development Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Myelination Axon Ensheathment Glial Cell Differentiation Plasma Membrane Organization Positive Regulation Of Cell Cycle Process Gliogenesis Positive Regulation Of Cell Cycle Response To Hypoxia Response To Metal Ion Endomembrane System Organization Response To Inorganic Substance Leukocyte Activation Regulation Of Cell Cycle Process
Tagcloud ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	augments becomes ccne1 cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Difference) ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	augments becomes ccne1 cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Intersection) ?