NDRG1 and DDX1

Number of citations of the paper that reports this interaction (PubMedID 17220478)
0

Data Source:
HPRD (in vivo)

		NDRG1	DDX1
Description		N-myc downstream regulated 1	DEAD-box helicase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Membrane Cleavage Body TRNA-splicing Ligase Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding Transcription Coregulator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Nuclease Activity Exonuclease Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity DNA/RNA Helicase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Spliceosomal Complex Assembly Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Double-strand Break Repair TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing Regulation Of Translational Initiation TRNA Processing Response To Virus Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Innate Immune Response Defense Response To Virus Protein Localization To Cytoplasmic Stress Granule
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	tRNA processing in the nucleus
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Asthma or chronic obstructive pulmonary disease ( 24993907) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 22479191) Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 30604766 31451708 31152163 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney volume ( 34128465) Metabolite levels ( 23823483) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Urate levels ( 31578528) Wilms tumor ( 22544364)
Interacting Genes		71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155	88 interacting genes: APP ATM CEBPA CSTF2 EIF4ENIF1 ESR1 HNRNPK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NDRG1 NME7 PTEN RELA RNF10 SNCA SUMO2 WEE2-AS1 YWHAQ
Entrez ID		10397	1653
HPRD ID		05586	03158
Ensembl ID		ENSG00000104419	ENSG00000079785
Uniprot IDs		Q8N959 Q92597	A3RJH1 Q92499
PDB IDs		6ZMM	4XW3 8TBX
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Angiogenesis Negative Regulation Of Locomotion Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Developmental Process Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Regulation Of RNA Stability Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Locomotion Extracellular Space Regulation Of Cell Motility Positive Regulation Of Catabolic Process Regulation Of MRNA Metabolic Process
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