NDRG1 and SHMT2

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		NDRG1	SHMT2
Gene Name		N-myc downstream regulated 1	serine hydroxymethyltransferase 2 (mitochondrial)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding	Chromatin Binding Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint	L-serine Biosynthetic Process One-carbon Metabolic Process Positive Regulation Of Cell Proliferation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Protein Homotetramerization
Pathways
Drugs			Pyridoxal Phosphate Tetrahydrofolic acid Glycine
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155	6 interactors: APP ARL6IP1 CMTM5 CSNK2B NDRG1 PPARD
Entrez ID		10397	6472
HPRD ID		05586	00717
Ensembl ID		ENSG00000104419	ENSG00000182199
Uniprot IDs		Q8N959 Q92597	B4DJQ3 P34897 Q5BJF5 Q5HYG8
PDB IDs			3OU5
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Locomotion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Chemotaxis Cellular Response To Oxygen Levels Cholesterol Metabolic Process Sterol Metabolic Process Response To External Stimulus Synaptic Growth At Neuromuscular Junction Hormone-mediated Signaling Pathway Axon Ensheathment Collateral Sprouting In Absence Of Injury Negative Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle Process Negative Regulation Of Cellular Component Movement Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Locomotion Keratinocyte Migration Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Steroid Metabolic Process Regulation Of Binding Response To Abiotic Stimulus Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Adiponectin-activated Signaling Pathway Vitamin A Metabolic Process Positive Regulation Of Cell Cycle Response To Hypoxia Neuron Remodeling Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Cell Cycle Checkpoint Endothelial Tube Morphogenesis Alcohol Metabolic Process Keratinocyte Proliferation MRNA Transcription Axon Guidance Negative Regulation Of Smooth Muscle Cell Migration Movement Of Cell Or Subcellular Component Cellular Copper Ion Homeostasis Peripheral Nervous System Myelin Maintenance Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Cell Differentiation Regulation Of Activin Receptor Signaling Pathway
Tagcloud ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread
Tagcloud (Difference) ?		4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw	anticancer cancerogenesis capacities carbons controlling depend directs fuels glycine hot hydroxymethyltransferase importantly isoform metabolism novo nucleotides overexpressed player precursors reprogramming serine shift shmt1 starvation thymidilate towards uracil widespread
Tagcloud (Intersection) ?