VCP and PLAA

Number of citations of the paper that reports this interaction (PMID 19887378)
5

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		VCP	PLAA
Gene Name		valosin containing protein	phospholipase A2-activating protein
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding	Protein Binding Phospholipase A2 Activator Activity
	Biological Process	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity	Phospholipid Metabolic Process Inflammatory Response Signal Transduction Positive Regulation Of Catalytic Activity
Pathways		HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS			Schizophrenia ( 20185149)
Protein-Protein Interactions		72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B	6 interactors: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP
Entrez ID		7415	9373
HPRD ID		03013	04850
Ensembl ID		ENSG00000165280	ENSG00000137055
Uniprot IDs		P55072 Q96IF9	Q9Y263
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW	2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling	Aggresome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Protein Catabolic Process Cellular Response To Heat Intracellular Transport Proteolysis Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Hsp90 Deacetylation Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Programmed Cell Death Cellular Response To Topologically Incorrect Protein Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Response To Heat Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Localization In Cell Protein Polyubiquitination Multicellular Organismal Lipid Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Complex Assembly Response To Temperature Stimulus Interleukin-8 Production Activation Of Phospholipase A2 Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation
Tagcloud (Difference) ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation
Tagcloud (Intersection) ?