VCP and RNF10

Number of citations of the paper that reports this interaction (PubMedID 37723588)
61

Data Source:
BioGRID (unspecified method)

		VCP	RNF10
Description		valosin containing protein	ring finger protein 10
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Cytoplasmic Stress Granule Protein-containing Complex VCP-NPL4-UFD1 AAA ATPase Complex Secretory Granule Lumen Azurophil Granule Lumen Site Of Double-strand Break Ciliary Basal Body Derlin-1 Retrotranslocation Complex Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Ficolin-1-rich Granule Lumen ATPase Complex VCP-NSFL1C Complex	Nucleus Cytoplasm Cytosolic Ribosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Lipid Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity K48-linked Polyubiquitin Modification-dependent Protein Binding MHC Class I Protein Binding Identical Protein Binding ADP Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy DNA Damage Response Canonical NF-kappaB Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Mitochondrial Membrane Potential Macroautophagy Protein Ubiquitination Viral Genome Replication NAD+ Metabolic Process Translesion Synthesis Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cellular Response To Heat Negative Regulation Of Hippo Signaling Stress Granule Disassembly Interstrand Cross-link Repair ERAD Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Negative Regulation Of Smoothened Signaling Pathway ATP Metabolic Process Regulation Of Synapse Organization Mitotic Spindle Disassembly Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Aggresome Assembly Cellular Response To Misfolded Protein Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Autophagosome Maturation Protein-DNA Covalent Cross-linking Repair Negative Regulation Of Protein Localization To Chromatin Cytoplasm Protein Quality Control Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Cellular Response To Arsenite Ion Positive Regulation Of Oxidative Phosphorylation Regulation Of Protein Localization To Chromatin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATP Biosynthetic Process	Protein Monoubiquitination Negative Regulation Of Schwann Cell Proliferation Protein Ubiquitination Positive Regulation Of Myelination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Autoubiquitination Postsynapse To Nucleus Signaling Pathway Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation Neddylation RHOH GTPase cycle Aggrephagy Attachment and Entry Attachment and Entry KEAP1-NFE2L2 pathway AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Phenethyl Isothiocyanate
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Response to quetiapine in schizophrenia ( 29503163)	Chronotype ( 26955885) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sensorimotor dexterity ( 31596458) Type 1 diabetes nephropathy ( 23028342)
Interacting Genes		98 interacting genes: ABHD17C AMFR ANKRD13A AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BAG5 BRCA1 BRSK2 BUD23 CACNA1C CEP19 CLUAP1 CRMP1 CSTF1 DERL1 DGCR6 DTNB ELAVL1 EPHB4 EPSTI1 ESR1 GZMK HDAC6 HTT INSIG1 INSIG2 JAK2 LINC01554 LNX1 LZIC MAPK8IP2 MDM2 METTL17 NDRG1 NF1 NFKBIA NGLY1 NOD2 NSFL1C NTAQ1 NUB1 OPTN PBK PIK3R3 PLAA PPP1CC PPP1R11 PPP1R3A PPP1R7 PRKCD PSMA1 PSMC1 PTPN3 RIPK4 RNF10 RNF115 RNF19A RNF8 RPS6KA1 SELENOS SH2D2A SLC43A3 SNCA SPRTN STUB1 STX5 SUMO4 SVIP TMUB1 TOM1L1 TOMM34 TRIM54 UBASH3A UBC UBE4A UBE4B UBOX5 UBXN10 UBXN11 UBXN2B UBXN4 UBXN6 UFD1 USP7 VAMP2 VANGL2 VCF1 VCPIP1 VCPKMT WAC WRN XAF1 YWHAZ ZBTB25	380 interacting genes: AARS2 ACIN1 ACO1 ACO2 ACTN4 AFDN AFF2 AGGF1 AGO4 AKAP1 AKAP8 ALDH18A1 ANK3 ANKHD1 ANKRD17 ARHGEF1 ARHGEF2 ASCC3 ASH1L ATP1A1 ATXN1 BARD1 BAZ1B BAZ2B BCLAF1 BMS1 BTG3 CACTIN CALD1 CAND1 CAPRIN2 CARS1 CC2D1B CCAR1 CCAR2 CCDC90B CDC5L CDK11B CDK13 CEBPZ CELF1 CELF2 CFAP65 CGN CHD3 CMTR1 CMTR2 CNOT10 COL14A1 COL4A5 COPB1 COPG1 CPSF2 CRNKL1 CSDE1 CSE1L CTNNA1 CWC22 DDX1 DDX10 DDX23 DDX24 DDX27 DDX31 DDX42 DDX46 DDX54 DDX60 DDX60L DGCR8 DHX16 DHX32 DHX34 DHX36 DHX38 DHX9 DIS3 DMGDH DNAAF2 DNM1 DNTTIP2 DROSHA DSCR9 DSP DYNC2H1 DYSF DZIP1 EEF1A1 EFL1 EIF2AK3 EIF2AK4 EIF2B5 EIF3A EIF3C EIF3D EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 ELAC2 ELOA EPB41 EPB41L2 EPPK1 EPRS1 ERN1 ERN2 ESF1 FAM120A FAM120B FAM120C FASTKD5 FBRSL1 FLNA FTSJ3 FUBP3 GANAB GCFC2 GCN1 GEMIN4 GEMIN5 GFM1 GFM2 GIGYF2 GOLGA4 GOLGB1 GRB2 HDLBP HEATR1 HERC5 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HOOK1 HSP90B1 HSPA9 HTATSF1 HUWE1 IARS1 IFIH1 IMMT INTS1 INTS2 INTS4 INTS5 INTS8 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 KDM1A KDM5A KIF1C KMT2C KPNB1 KTN1 L1TD1 LARP1 LARP1B LARS1 LONP1 LRIF1 LRP1 LRPPRC LRRFIP1 MAP1B MAP4 MARS1 MATR3 MDM2 MKRN3 MOV10 MOV10L1 MPHOSPH10 MTCL1 MVP MYBBP1A MYH14 MYH9 MYO18A NAA15 NCBP1 NCL NKTR NLRP11 NOC2L NOC3L NOL8 NOP14 NOP2 NOVA1 NOVA2 NSF NSUN2 NUMA1 NVL OAS3 PAN3 PARP1 PARP4 PC PDCD11 PDCD6IP PDS5A PIWIL1 PIWIL2 PIWIL3 PIWIL4 PKN2 PMS1 PNPT1 POLR2A PPARGC1A PPIG PRKDC PRP4K PRPF40A PRPF40B PRPF6 PRRC2C PTBP1 QARS1 R3HCC1L RANBP17 RANBP2 RANBP6 RBM10 RBM12B RBM15B RBM19 RBM25 RBM27 RBM28 RBM4 RBM44 RBM5 RBM6 RIMS1 RNASEL RNF17 ROCK2 RPGR RPS10 RPS20 RPS3 RRBP1 RSPH1 RTN4 SAFB2 SART1 SART3 SCAF11 SCAF8 SEC23IP SEC63 SECISBP2 SECISBP2L SETD1B SETDB1 SETX SF3A1 SF3B2 SF3B3 SIDT1 SIDT2 SLC4A1AP SMG1 SMG6 SMG8 SNCA SND1 SNRNP200 SORBS1 SPTBN1 SPTBN5 SRBD1 SRP68 SRSF1 SRSF3 STK10 SUB1 SUGP2 SUPT16H SUPT6H SUPV3L1 SUZ12 SWT1 SYMPK SYNE2 TARBP1 TARBP2 TARS1 TARS3 TASOR TBL3 TCERG1 TCF20 TDRD1 TDRD12 TDRD5 TDRD6 TDRD7 TDRD9 TENT4A TEP1 TERF1 TFIP11 TGS1 THRAP3 TIPARP TLE1 TLR3 TLR7 TLR8 TNPO1 TNPO2 TNPO3 TNRC6B TNS1 TOP2A TPX2 TRIM55 TRIM63 TRMT44 TULP3 TUT7 U2SURP UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2H UBE2I UBE2J2 UBE2O UBE2U UBE2V1 UBE2W UBTD1 UBTF UNK UNKL UPF1 URB1 USO1 USP42 UTP14A UTP14C UTP20 VARS1 VCP VIL1 VIRMA WDR36 WDR43 WDR75 XAB2 XIRP1 XPO4 XPO6 XPO7 XPOT XRCC6 XRN1 XRN2 YBX1 ZBTB48 ZC3H11A ZC3H13 ZC3H4 ZCCHC2 ZFC3H1 ZFR ZFR2 ZNF106 ZNF346 ZNFX1
Entrez ID		7415	9921
HPRD ID		03013	11496
Ensembl ID		ENSG00000165280	ENSG00000022840
Uniprot IDs		C9JUP7 P55072	A0A024RBP0 Q8N5U6
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW 4KDI 4KDL 4KLN 4KO8 4KOD 4P0A 5B6C 5C18 5C19 5C1A 5C1B 5DYG 5DYI 5EPP 5FTJ 5FTK 5FTL 5FTM 5FTN 5GLF 5IFS 5IFW 5KIW 5KIY 5X4L 6G2V 6G2W 6G2X 6G2Y 6G2Z 6G30 6HD0 6MCK 7BP8 7BP9 7BPA 7BPB 7JY5 7K56 7K57 7K59 7L5W 7L5X 7LMY 7LMZ 7LN0 7LN1 7LN2 7LN3 7LN4 7LN5 7LN6 7MDM 7MDO 7MHS 7OAT 7PUX 7R7S 7R7T 7R7U 7RL6 7RL7 7RL9 7RLA 7RLB 7RLC 7RLD 7RLF 7RLG 7RLH 7RLI 7RLJ 7VCS 7VCT 7VCU 7VCV 7VCX 7Y4W 7Y53 7Y59 8B5R 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT 8HL7 8HRZ 8KG2 8OOI 8PQX 8R0E 8RS9 8RSB 8RSC 8UV2 8UVO 8UVP 8UVQ 8VKU 8VLS 8VOV 8YKA 9BOQ
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Protein Metabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process ERAD Pathway Catabolic Process Ubiquitin Binding Cellular Response To Stress Macromolecule Metabolic Process Post-translational Protein Modification ATPase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signal Transduction Protein Modification Process Cellular Response To Misfolded Protein Positive Regulation Of Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Topologically Incorrect Protein Ubiquitin Protein Ligase Activity Response To Stress Ubiquitin-ubiquitin Ligase Activity Intracellular Signal Transduction Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Cytosol Ubiquitin Protein Ligase Binding Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Regulation Of Protein Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Intracellular Transport Golgi Organization Nucleus Protein Polyubiquitination Postsynapse Protein Binding Negative Regulation Of Proteolysis	RNA Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process MRNA Processing Nucleus RNA Splicing Macromolecule Metabolic Process Nucleoplasm Nucleolus RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Helicase Activity Helicase Activity Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression ATP Binding RNA Catabolic Process Double-stranded RNA Binding Catalytic Step 2 Spliceosome Regulation Of Gene Expression Nuclear Speck Regulation Of Macromolecule Biosynthetic Process ATP Hydrolysis Activity Cytoplasm Regulation Of RNA Splicing Regulation Of Translation Negative Regulation Of Gene Expression Regulation Of MRNA Processing RRNA Metabolic Process Spliceosomal Complex Nucleotide Binding MRNA Binding Regulation Of MRNA Stability Regulation Of RNA Stability RRNA Processing Regulation Of Macromolecule Metabolic Process Nucleocytoplasmic Transport Nuclear Transport PiRNA Processing Ribonucleoprotein Complex Regulation Of Primary Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?