NDRG1 and ACTG1

Number of citations: 0 (PubMedID 17220478)
Data Source: HPRD (in vivo)

		NDRG1	ACTG1
Name		N-myc downstream regulated 1	actin gamma 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Myofibril Axon Filamentous Actin NuA4 Histone Acetyltransferase Complex Apical Junction Complex Calyx Of Held Apical Part Of Cell Synapse Phagocytic Vesicle Extracellular Exosome Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Basal Body Patch
	Molecular Function	Protein Binding Microtubule Binding Nickel Cation Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Hydrolase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia	Angiogenesis Morphogenesis Of A Polarized Epithelium Axonogenesis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Sarcomere Organization Cell Motility Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Platelet Aggregation Cellular Response To Type II Interferon Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Regulation Of Synaptic Vesicle Endocytosis Protein Localization To Bicellular Tight Junction
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		None	Copper Artenimol
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	None
GWAS		Estimated glomerular filtration rate ( 31015462 ) Left-handedness ( 32989287 ) Nontyphoidal Salmonella bacteraemia ( 29523850 ) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511 )	Alanine aminotransferase levels ( 33339817 33547301 ) Gamma glutamyl transferase levels ( 33339817 ) Hand grip strength ( 29313844 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Refractive error ( 32231278 )
Interacting Genes		71 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E ETS2 EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155	72 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CEBPA CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FNDC3B FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC00941 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WEE2-AS1 WIPF1
Entrez ID		10397	71
HPRD ID		05586	00017
Ensembl ID		ENSG00000104419	ENSG00000184009
Uniprot IDs		Q8N959 Q92597	P63261
PDB IDs		6ZMM	5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2 7NVM 8DNF
GO Terms Enriched among Interactors		Ribonucleoprotein Complex Extracellular Exosome Cytosol RNA Binding Macromolecule Metabolic Process Translation Cytosolic Ribosome Macromolecule Biosynthetic Process Cadherin Binding Response To Cytokine Protein Metabolic Process Response To Peptide Secretory Granule Lumen Cellular Response To Cytokine Stimulus Cytoplasmic Translation Membrane Nucleoplasm ATP Hydrolysis Activity Regulation Of Protein Metabolic Process Ribosome Nucleobase-containing Compound Metabolic Process Cytosolic Small Ribosomal Subunit Structural Constituent Of Ribosome Regulation Of Primary Metabolic Process Small Ribosomal Subunit Nucleotide Binding Protein-RNA Complex Assembly Regulation Of Translation ATP Binding Nucleic Acid Metabolic Process Regulation Of Telomere Maintenance Protein Binding Catabolic Process RNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Ficolin-1-rich Granule Lumen Protein-containing Complex Organization Regulation Of RNA Splicing Macromolecule Catabolic Process Cytoplasm Focal Adhesion Positive Regulation Of Biosynthetic Process Nucleus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Disordered Domain Specific Binding Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression	Actin Binding Actin Filament Organization Actin Filament-based Process Regulation Of Actin Filament Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Actin Filament Binding Cytoskeleton Actin Cytoskeleton Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Actin Filament Severing Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Regulation Of Protein Depolymerization Lamellipodium Cell Projection Organization Cytoplasm Modification Of Postsynaptic Structure Positive Regulation Of Cellular Component Organization Modification Of Synaptic Structure Regulation Of Protein-containing Complex Disassembly Glutamatergic Synapse Positive Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cytoskeleton Organization Actin Filament Fragmentation Protein Depolymerization Organelle Organization Plasma Membrane Bounded Cell Projection Organization Presynapse Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Protein Depolymerization Barbed-end Actin Filament Capping Positive Regulation Of Cellular Component Biogenesis