VCP and BRSK2

Number of citations of the paper that reports this interaction (PMID 23907667)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		VCP	BRSK2
Gene Name		valosin containing protein	BR serine/threonine kinase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Hrd1p Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Site Of Double-strand Break Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Centrosome Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding ATP Binding Lipid Binding ATPase Activity Protein Phosphatase Binding Protein Domain Specific Binding Polyubiquitin Binding Protein Complex Binding Deubiquitinase Activator Activity Identical Protein Binding ADP Binding Poly(A) RNA Binding Ubiquitin-specific Protease Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Tau-protein Kinase Activity
	Biological Process	DNA Repair Double-strand Break Repair ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Translesion Synthesis ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Hexamerization Cellular Response To Heat Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Protein Homooligomerization Aggresome Assembly Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Lys63-specific Deubiquitinase Activity	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Mitotic Nuclear Division Axonogenesis Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Actin Cytoskeleton Reorganization Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		HSF1 activation Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog Cellular response to heat stress
Drugs
Diseases
GWAS
Protein-Protein Interactions		72 interactors: AMFR AR ASPSCR1 ATG5 ATXN1 ATXN3 ATXN7 BRCA1 BRSK2 CAV1 CEP19 CRMP1 DERL1 DGCR6 DTNB FAM104A GZMK HDAC6 HERPUD1 HTT INSIG1 INSIG2 JAK2 LNX1 MAPK8IP2 NDRG1 NF1 NFKBIA NGLY1 NPLOC4 NSFL1C NUB1 OTULIN PLAA PRKCD PSMA1 PSMA7 PSMC1 PTPN3 RNF19A RNF31 RNF8 RPL9 RPS6KA1 SH2D2A SIK2 STUB1 STX5 SUMO4 SVIP SYVN1 TOM1L1 TOMM34 UBE4A UBE4B UBOX5 UBQLN1 UBXN1 UBXN2A UBXN2B UBXN6 UFD1L VCPIP1 VCPKMT VIMP WAC WBSCR22 WDYHV1 WRN YOD1 YWHAZ ZFAND2B	4 interactors: CDC25B CDC25C VCP WEE1
Entrez ID		7415	9024
HPRD ID		03013	11611
Ensembl ID		ENSG00000165280	ENSG00000174672
Uniprot IDs		P55072 Q96IF9	B3KVE9 B4DLY3 E9PLM7 Q8IWQ3
PDB IDs		3EBB 3HU1 3HU2 3HU3 3QC8 3QQ7 3QQ8 3QWZ 3TIW
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Modification By Small Protein Conjugation Protein Ubiquitination Response To Stress Catabolic Process Protein Metabolic Process Protein Polyubiquitination Cellular Metabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Cellular Response To Topologically Incorrect Protein ER-nucleus Signaling Pathway Golgi Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stimulus Negative Regulation Of Apoptotic Process Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Negative Regulation Of Cellular Protein Metabolic Process Apoptotic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cellular Response To Unfolded Protein Programmed Cell Death Negative Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Signal Transduction Response To Stimulus Response To Unfolded Protein Negative Regulation Of Signaling	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Cell Cycle Peptidyl-tyrosine Dephosphorylation Cell Cycle Process Cellular Protein Modification Process Protein Dephosphorylation Regulation Of Cell Division Cell Cycle Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Deubiquitination Protein Hexamerization Cellular Protein Metabolic Process Aggresome Assembly Regulation Of Mitotic Cell Cycle Translesion Synthesis Regulation Of Cellular Protein Metabolic Process Dephosphorylation Female Meiosis I Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Protein Metabolic Process Postreplication Repair Regulation Of Catalytic Activity Oocyte Maturation Gamete Generation Regulation Of Protein Kinase Activity Female Meiotic Division Regulation Of Kinase Activity Sexual Reproduction Phosphate-containing Compound Metabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Oocyte Development Oocyte Differentiation Positive Regulation Of Protein Modification Process Organelle Organization Peptidyl-amino Acid Modification Regulation Of Cytokinesis Reproduction Cellular Response To Heat
Tagcloud ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	aicar ampk ampkbeta blunted brsk1 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1
Tagcloud (Difference) ?		17q11 3q28 9pter ap2 ap50 aps blots clapb1 clapm1 clathrin coated denoted designated dnas endocytosis lattice locations mapped maps oligonucleotide porcine primers probe q12 q34 rodent served stoichiometric triskelia	aicar ampk ampkbeta blunted brsk1 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1
Tagcloud (Intersection) ?