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ACTC1 and CAPN1
Number of citations of the paper that reports this interaction (PubMedID
12358155
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ACTC1
CAPN1
Description
actin alpha cardiac muscle 1
calpain 1
Image
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Focal Adhesion
Actin Cytoskeleton
Membrane
Sarcomere
Lamellipodium
Filopodium
I Band
Cell Body
Synapse
Extracellular Exosome
Blood Microparticle
Glutamatergic Synapse
Cornified Envelope
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Calpain Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Microfilament Motor Activity
Nucleotide Binding
Protein Binding
ATP Binding
Hydrolase Activity
Myosin Binding
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Metal Ion Binding
Biological Process
Actin Filament Organization
Response To Xenobiotic Stimulus
Positive Regulation Of Gene Expression
Actin Filament-based Movement
Skeletal Muscle Thin Filament Assembly
Actomyosin Structure Organization
Actin-myosin Filament Sliding
Negative Regulation Of Apoptotic Process
Response To Ethanol
Cardiac Myofibril Assembly
Cardiac Muscle Tissue Morphogenesis
Heart Contraction
Cardiac Muscle Contraction
Cytoplasmic Actin-based Contraction Involved In Cell Motility
Mesenchyme Migration
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Receptor Catabolic Process
Regulation Of Catalytic Activity
Mammary Gland Involution
Self Proteolysis
NMDA Selective Glutamate Receptor Signaling Pathway
Pathways
Striated Muscle Contraction
RHOA GTPase cycle
RHOB GTPase cycle
Regulation of CDH1 Function
Formation of the dystrophin-glycoprotein complex (DGC)
Formation of the dystrophin-glycoprotein complex (DGC)
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
Dilated cardiomyopathy (DCM)
Hypertrophic cardiomyopathy (HCM)
Atrial septal defect
GWAS
Axial length (
24144296
)
Refractive error (
20835239
32231278
)
Urate levels (
31578528
)
Interacting Genes
43 interacting genes:
ABLIM3
ABRA
ACTB
ACTN4
ACTR2
AFAP1
ANG
ASH2L
BCL11A
C1QTNF9
CAPN1
CFL1
DMD
DMTN
DYNLL1
EZR
FBXO7
FSCN1
GAPDH
GC
HSPB1
HSPB2
KAT14
KLHL17
KLHL2
KPTN
LASP1
LINC00624
MIB2
MPC1
MYLK
OGT
PLEC
PRKCE
SCIN
SLC4A1
SYNE1
SYNE2
TNNI3K
TWF1
UBC
WAS
WIPF1
55 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KCTD7
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
Entrez ID
70
823
HPRD ID
00015
00253
Ensembl ID
ENSG00000159251
ENSG00000014216
Uniprot IDs
B3KPP5
P68032
B2RDI5
B4DWH5
P07384
PDB IDs
8GSU
8GSW
8GT1
8GT2
8GT3
8GT4
8GT5
8ZB7
8ZI9
8ZJ1
9B3Q
9B3R
1ZCM
2ARY
7W7O
7X79
8GX3
Enriched GO Terms of Interacting Partners
?
Actin Binding
Actin Cytoskeleton
Actin Filament Binding
Cytoskeleton
Actin Filament-based Process
Actin Filament Organization
Cytoplasm
Focal Adhesion
Regulation Of Lamellipodium Assembly
Actin Filament
Supramolecular Fiber Organization
Regulation Of Lamellipodium Organization
Actin Polymerization Or Depolymerization
Actin Cytoskeleton Organization
Myofibril
Cell Projection Assembly
Lamellipodium
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Cytoskeleton Organization
Regulation Of Cell Projection Organization
Cortical Cytoskeleton
Z Disc
Postsynaptic Actin Cytoskeleton
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Regulation Of Cell Projection Assembly
Filopodium
Regulation Of Actin Cytoskeleton Organization
Stress Fiber
Plasma Membrane Bounded Cell Projection Assembly
Negative Regulation Of Actin Filament Depolymerization
Regulation Of Cellular Component Size
Regulation Of Actin Filament-based Process
Cell Projection
Regulation Of Actin Filament Depolymerization
Regulation Of Protein-containing Complex Assembly
Brush Border
Regulation Of Actin Filament Polymerization
Actin Filament-based Movement
Extracellular Exosome
Cytosol
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Lamellipodium Assembly
Negative Regulation Of Protein-containing Complex Disassembly
Negative Regulation Of Cytoskeleton Organization
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Cytoskeleton Organization
Establishment Or Maintenance Of Cell Polarity
Regulation Of Actin Filament Organization
Cell Projection Organization
Organelle Organization
Regulation Of Programmed Cell Death
Response To Alcohol
Regulation Of Organelle Organization
Regulation Of Apoptotic Process
Identical Protein Binding
Positive Regulation Of Organelle Organization
Regulation Of Multicellular Organismal Process
Protease Binding
Cytoplasm
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Developmental Process
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Gene Expression
Response To Lipid
Positive Regulation Of Programmed Cell Death
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Negative Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Hepatocyte Apoptotic Process
Cytosol
Regulation Of Actin Filament Depolymerization
Negative Regulation Of Apoptotic Process
Cell Junction Maintenance
Regulation Of Renin Secretion Into Blood Stream
Regulation Of Autophagy
Sarcomere
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Filament-based Process
Regulation Of Mitochondrial Membrane Permeability
G-protein Beta-subunit Binding
Regulation Of Protein Localization
Response To Amino Acid
Release Of Cytochrome C From Mitochondria
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Response To Fluoride
Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Apoptotic Process
Cellular Component Maintenance
Regulation Of Membrane Permeability
Cysteine-type Peptidase Activity
Positive Regulation Of Cellular Component Organization
Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Protein Localization
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