ACTC1 and DMTN

Number of citations of the paper that reports this interaction (PMID 12011427)
22

Data Source:
HPRD (in vivo)

		ACTC1	DMTN
Gene Name		actin, alpha, cardiac muscle 1	dematin actin binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Cytosol Actin Filament Plasma Membrane Endomembrane System Spectrin-associated Cytoskeleton Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Receptor Binding Protein Binding Spectrin Binding Protein Self-association
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Protein Complex Assembly Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	13 interactors: ACTB ACTC1 APP DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB
Entrez ID		70	2039
HPRD ID		00015	00506
Ensembl ID		ENSG00000159251	ENSG00000158856
Uniprot IDs		B3KPP5 P68032	B4DI75 Q08495
PDB IDs			1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Immune System Process Movement Of Cell Or Subcellular Component Regulation Of Tight Junction Assembly Cellular Response To Epinephrine Stimulus Response To Epinephrine Blood Coagulation Regulation Of Protein Binding Cell Maturation Hemostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Cellular Response To Catecholamine Stimulus Platelet Activation Ion Homeostasis Regulation Of Body Fluid Levels Cell Development Negative Regulation Of Transporter Activity Negative Regulation Of Nucleotide Metabolic Process Wound Healing Chemotaxis Regulation Of Binding Locomotion Cell Activation Immune Response Response To Wounding Regulation Of Cell Junction Assembly Water Homeostasis Homeostatic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Innate Immune Response Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Membrane Organization Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Anatomical Structure Morphogenesis Response To Interleukin-1 Regulation Of Striated Muscle Contraction Regulation Of Phospholipase Activity Negative Regulation Of Protein Polymerization Axon Guidance Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	apoe apolipoprotein app appl dementin developmental disrupted drosophila ectopic flies genetically glia glial hypomorphic interacted lethal lethality medulla metabolites microtubule mis named neurodegeneration neuropil orthologue rescued resembling rnai tmcc2
Tagcloud (Intersection) ?