ACTC1 and AFAP1

Number of citations of the paper that reports this interaction (PubMedID 12134071)
41

Data Source:
HPRD (in vivo)

		ACTC1	AFAP1
Description		actin alpha cardiac muscle 1	actin filament associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Stress Fiber Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding	Actin Binding
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration	Regulation Of Signal Transduction
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Axial length ( 24144296) Refractive error ( 20835239 32231278)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 25861811 33627673 29452408 25173105 27623284 29891935) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Intraocular pressure ( 29617998 29235454 31959993 30054594 29785010) Lung function (FEV1/FVC) ( 30804560 30061609) Medication use (antiglaucoma preparations and miotics) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 27618447) Response to antidepressants (symptom improvement) ( 29160301) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	9 interacting genes: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC
Entrez ID		70	60312
HPRD ID		00015	09747
Ensembl ID		ENSG00000159251	ENSG00000196526
Uniprot IDs		B3KPP5 P68032	Q6ZRV0 Q8N556
PDB IDs		8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization	Diacylglycerol-dependent Serine/threonine Kinase Activity ATP Binding Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity Nucleotide Binding Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Phosphorylation Protein Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Hormone Response To Peptide Hormone Fc Receptor Mediated Stimulatory Signaling Pathway Histone H3T6 Kinase Activity Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Negative Regulation Of Programmed Cell Death Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Cell-cell Junction Mesenchyme Migration Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transferase Activity Skeletal Muscle Thin Filament Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Signaling Receptor Activator Activity Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Immune Response Actin Filament Extracellular Exosome Positive Regulation Of Insulin Secretion Negative Regulation Of Glial Cell Apoptotic Process Perinuclear Region Of Cytoplasm Mitotic Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Phosphate-containing Compound Metabolic Process
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