ACTC1 and TWF1

Number of citations of the paper that reports this interaction (PMID 12207032)
12

Data Source:
HPRD (in vivo)

		ACTC1	TWF1
Gene Name		actin, alpha, cardiac muscle 1	twinfilin actin-binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Cell-cell Junction Focal Adhesion Actin Cytoskeleton Myofibril Filopodium Ruffle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Monomer Binding Protein Tyrosine Kinase Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Negative Regulation Of Actin Filament Polymerization Sequestering Of Actin Monomers Regulation Of Actin Phosphorylation
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	4 interactors: ACTC1 APP BMPR2 FBXO25
Entrez ID		70	5756
HPRD ID		00015	10174
Ensembl ID		ENSG00000159251	ENSG00000151239
Uniprot IDs		B3KPP5 P68032	Q12792
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Collateral Sprouting In Absence Of Injury Negative Regulation Of Vasoconstriction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Developmental Growth Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Blood Circulation Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Positive Regulation Of Axon Extension Involved In Axon Guidance Skeletal Myofibril Assembly Lymphatic Endothelial Cell Differentiation Neuron Remodeling Cell Development Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Cellular Copper Ion Homeostasis Regulation Of Neuron Differentiation Retina Vasculature Development In Camera-type Eye Copper Ion Homeostasis Suckling Behavior Lymph Vessel Development Regulation Of Growth Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Cardiac Myofibril Assembly Anatomical Structure Morphogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Tissue Morphogenesis Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Neurogenesis Activin Receptor Signaling Pathway Actin-myosin Filament Sliding Muscle Filament Sliding Mating Behavior Chondrocyte Development Endoplasmic Reticulum Calcium Ion Homeostasis Brain Development RNA Polyadenylation Neuron Recognition Positive Regulation Of BMP Signaling Pathway Head Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?