CAPN1 and ACTN2

Number of citations of the paper that reports this interaction (PMID 12358155)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CAPN1	ACTN2
Gene Name		calpain 1, (mu/I) large subunit	actinin, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Degradation of the extracellular matrix	Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		823	88
HPRD ID		00253	00019
Ensembl ID		ENSG00000014216	ENSG00000077522
Uniprot IDs		B2RDI5 B4DWH5 P07384	B2RCS5 P35609 Q59FD9
PDB IDs		1ZCM 2ARY	1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?