CAPN1 and ARF6

Number of citations of the paper that reports this interaction (PubMedID 16737952)
0

Data Source:
HPRD (in vitro)

		CAPN1	ARF6
Description		calpain 1	ARF GTPase 6
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Urate levels ( 31578528)	Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)
Interacting Genes		55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709
Entrez ID		823	382
HPRD ID		00253	02714
Ensembl ID		ENSG00000014216	ENSG00000165527
Uniprot IDs		B2RDI5 B4DWH5 P07384	P62330
PDB IDs		1ZCM 2ARY 7W7O 7X79 8GX3	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization	Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion
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