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CAPN1 and HNRNPD
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
CAPN1
HNRNPD
Description
calpain 1
heterogeneous nuclear ribonucleoprotein D
Image
GO Annotations
Cellular Component
Cornified Envelope
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Calpain Complex
Ficolin-1-rich Granule Lumen
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Postsynaptic Density
Synapse
Glutamatergic Synapse
MCRD-mediated MRNA Stability Complex
Ribonucleoprotein Complex
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Metal Ion Binding
Nucleic Acid Binding
DNA Binding
Minor Groove Of Adenine-thymine-rich DNA Binding
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Telomeric DNA Binding
Histone Deacetylase Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Receptor Catabolic Process
Regulation Of Catalytic Activity
Mammary Gland Involution
Self Proteolysis
NMDA Selective Glutamate Receptor Signaling Pathway
Liver Development
Regulation Of DNA-templated Transcription
RNA Processing
RNA Catabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Cerebellum Development
Positive Regulation Of Telomere Maintenance Via Telomerase
Response To Estradiol
Regulation Of Circadian Rhythm
Regulation Of MRNA Stability
Positive Regulation Of Translation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Calcium Ion
Response To Electrical Stimulus
3'-UTR-mediated MRNA Destabilization
CRD-mediated MRNA Stabilization
Cellular Response To Amino Acid Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Nitric Oxide
Circadian Regulation Of Translation
Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Response To Rapamycin
Positive Regulation Of Telomere Capping
Response To Sodium Phosphate
Cellular Response To Putrescine
Hepatocyte Dedifferentiation
Positive Regulation Of Cytoplasmic Translation
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Artenimol
Diseases
GWAS
Urate levels (
31578528
)
Chronotype (
30696823
)
Coronary artery disease (
32469254
33020668
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Morning person (
30696823
)
Refractive error (
32231278
)
Interacting Genes
55 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KCTD7
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
98 interacting genes:
ABCC10
ACTB
ADGRE5
ARF4
B3GAT3
BET1L
BRCA1
C1QBP
CAPN1
CD81
CEBPA
CINP
COG7
COL18A1
CSDE1
CTSB
CUTA
DGCR2
DHX30
DMAC1
EEF2
ERG
ESR1
EXOSC4
FBXL15
FILNC1
FLNA
FNDC3B
FOS
FOXP1
GSK3B
GTF3C3
GTSE1
GUK1
HBZ
HDAC1
HIRA
HMGA1
HNRNPH3
HSPA4
HSPB1
HSPB2
IGF2BP2
IL6
IL7R
IMMP2L
IMMT
ING4
LDHA
LINC01232
LSM5
MAP2K1
MAPK6
MEOX2
MPP1
MTA2
MYC
NEDD4L
NTMT1
OGT
P4HB
PABPC1
PCBP1
PCBP2
PCSK7
PDLIM7
PEX10
PPOX
PRDX3
PRKACA
PTBP2
PYCR1
RALY
RPSA
SAFB
SDF2
SEPTIN9
SF3B4
SFN
SHISA5
SLC27A5
SLC3A2
SNAPC4
SREK1
SUMO4
SYNCRIP
TNF
TNPO1
TOP2A
TRN-GTT2-7
TSEN34
UBE2I
UCP3
UQCRC1
VEGFA
VHL
YBX1
ZMYM4
Entrez ID
823
3184
HPRD ID
00253
03206
Ensembl ID
ENSG00000014216
ENSG00000138668
Uniprot IDs
B2RDI5
B4DWH5
P07384
Q14103
PDB IDs
1ZCM
2ARY
7W7O
7X79
8GX3
1HD0
1HD1
1IQT
1WTB
1X0F
2Z5N
5IM0
Enriched GO Terms of Interacting Partners
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Organelle Organization
Regulation Of Programmed Cell Death
Response To Alcohol
Regulation Of Organelle Organization
Regulation Of Apoptotic Process
Identical Protein Binding
Positive Regulation Of Organelle Organization
Regulation Of Multicellular Organismal Process
Protease Binding
Cytoplasm
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Developmental Process
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Gene Expression
Response To Lipid
Positive Regulation Of Programmed Cell Death
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Negative Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Hepatocyte Apoptotic Process
Cytosol
Regulation Of Actin Filament Depolymerization
Negative Regulation Of Apoptotic Process
Cell Junction Maintenance
Regulation Of Renin Secretion Into Blood Stream
Regulation Of Autophagy
Sarcomere
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Filament-based Process
Regulation Of Mitochondrial Membrane Permeability
G-protein Beta-subunit Binding
Regulation Of Protein Localization
Response To Amino Acid
Release Of Cytochrome C From Mitochondria
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Response To Fluoride
Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Apoptotic Process
Cellular Component Maintenance
Regulation Of Membrane Permeability
Cysteine-type Peptidase Activity
Positive Regulation Of Cellular Component Organization
Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Protein Localization
RNA Binding
CRD-mediated MRNA Stabilization
Macromolecule Metabolic Process
Positive Regulation Of Translation
Ribonucleoprotein Complex
Positive Regulation Of Cytoplasmic Translation
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression
MRNA Metabolic Process
Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Regulation Of Programmed Cell Death
RNA Metabolic Process
Nucleic Acid Binding
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Response To Stress
Negative Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Cytoplasmic Translation
MCRD-mediated MRNA Stability Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
CRD-mediated MRNA Stability Complex
Positive Regulation Of Gene Expression
Transcription Coregulator Binding
Regulation Of Gene Expression
Regulation Of Translation
Nucleic Acid Metabolic Process
Regulation Of MiRNA Transcription
Focal Adhesion
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Splicing
Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
MRNA Processing
Regulation Of Macromolecule Biosynthetic Process
Spliceosomal Complex
Nucleoplasm
Negative Regulation Of Catabolic Process
Regulation Of DNA-templated Transcription
Regulation Of MiRNA Metabolic Process
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Tagcloud (Intersection)
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