CAPN1 and IL1A

Number of citations of the paper that reports this interaction (PMID 7499244)
15

Data Source:
HPRD (in vitro)

		CAPN1	IL1A
Gene Name		calpain 1, (mu/I) large subunit	interleukin 1, alpha
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Apoptotic Process Inflammatory Response Immune Response Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Response To Copper Ion Positive Regulation Of Cytokine Secretion Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Degradation of the extracellular matrix	Signaling by Interleukins Interleukin-1 processing Cellular Senescence Interleukin-1 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Endometriosis ( 20844546) Working memory ( 21107309)
Protein-Protein Interactions		50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM	9 interactors: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP NDN NFKBIE S100A13
Entrez ID		823	3552
HPRD ID		00253	00988
Ensembl ID		ENSG00000014216
Uniprot IDs		B2RDI5 B4DWH5 P07384	P01583
PDB IDs		1ZCM 2ARY	1ITA 2ILA 2KKI 2L5X
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress	Cytokine Production Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Immune Response Response To Cytokine Response To Organic Substance Interleukin-1 Alpha Secretion Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Autophagy D-serine Transport Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Interleukin-2 Biosynthetic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Interleukin-1 Secretion Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Interleukin-2 Production Positive Regulation Of Granulocyte Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitochondrion Degradation Regulation Of Intracellular Protein Transport Interleukin-1-mediated Signaling Pathway Regulation Of Inflammatory Response Interleukin-1 Beta Production Receptor Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Actin Cytoskeleton Reorganization Respiratory System Process Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Cytokine Biosynthetic Process Response To Copper Ion Regulation Of Interleukin-1 Beta Secretion Axonal Fasciculation Cytoplasmic Sequestering Of Protein Positive Regulation Of Signal Transduction Response To Stimulus Mast Cell Degranulation
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter
Tagcloud (Intersection) ?