ACTC1 and ACTR2

Number of citations of the paper that reports this interaction (PubMedID 12019562)
167

Data Source:
HPRD (in vivo)

		ACTC1	ACTR2
Description		actin alpha cardiac muscle 1	actin related protein 2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Cell Projection Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding	Nucleotide Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Actin Cytoskeleton Organization Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Meiotic Cell Cycle Spindle Localization Cilium Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Axial length ( 24144296) Refractive error ( 20835239 32231278)	Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)
Interacting Genes		43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	19 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CEBPA ELF5 ERCC6 FILNC1 HCLS1 IQGAP2 LINC00632 PLK4 SHARPIN WAS WASF1 WASF2 WASL
Entrez ID		70	10097
HPRD ID		00015	05023
Ensembl ID		ENSG00000159251	ENSG00000138071
Uniprot IDs		B3KPP5 P68032	P61160
PDB IDs		8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization	Actin Filament Organization Actin Cytoskeleton Arp2/3 Complex-mediated Actin Nucleation Supramolecular Fiber Organization Actin Nucleation Actin Binding Arp2/3 Protein Complex Lamellipodium Actin Filament Polymerization Actin Filament Binding Actin Polymerization Or Depolymerization Arp2/3 Complex Binding Actin Filament-based Movement Regulation Of Cytoskeleton Organization Cytoskeleton Protein Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Actin Filament-based Process Site Of Double-strand Break Structural Constituent Of Cytoskeleton Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Lamellipodium Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization SCAR Complex Positive Regulation Of Actin Nucleation Focal Adhesion Trophoblast Giant Cell Differentiation Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Regulatory Subunit Binding Rac Protein Signal Transduction Protein Kinase A Binding GTPase Regulator Activity
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