ACTC1 and CFL1

Number of citations of the paper that reports this interaction (PMID 12207032)
12

Data Source:
HPRD (in vivo)

		ACTC1	CFL1
Gene Name		actin, alpha, cardiac muscle 1	cofilin 1 (non-muscle)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Protein Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis
Pathways		Striated Muscle Contraction	Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)	Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		70	1072
HPRD ID		00015	03261
Ensembl ID		ENSG00000159251	ENSG00000172757
Uniprot IDs		B3KPP5 P68032	P23528
PDB IDs			1Q8G 1Q8X 3J0S 4BEX
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?