ACTC1 and SLC4A1

Number of citations of the paper that reports this interaction (PMID 12898519)
3

Data Source:
HPRD (two hybrid, in vivo)

		ACTC1	SLC4A1
Gene Name		actin, alpha, cardiac muscle 1	solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Z Disc Cortical Cytoskeleton Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Inorganic Anion Exchanger Activity Protein Binding Protein C-terminus Binding Anion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Ankyrin Binding Protein Homodimerization Activity Protein Anchor
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Ion Transport Anion Transport Chloride Transport Cellular Ion Homeostasis Bicarbonate Transport Small Molecule Metabolic Process Regulation Of Intracellular PH Transmembrane Transport Chloride Transmembrane Transport
Pathways		Striated Muscle Contraction	O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Transport of inorganic cations/anions and amino acids/oligopeptides Erythrocytes take up oxygen and release carbon dioxide SLC-mediated transmembrane transport Bicarbonate transporters
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	13 interactors: ACTC1 ANK1 BLOC1S6 CA2 CA4 CANX CDKN2A EPB41 EPB42 LYN RHAG SLC4A1AP SYK
Entrez ID		70	6521
HPRD ID		00015	00175
Ensembl ID		ENSG00000159251	ENSG00000004939
Uniprot IDs		B3KPP5 P68032	P02730
PDB IDs			1BH7 1BNX 1BTQ 1BTR 1BTS 1BTT 1BZK 1HYN 2BTA 2BTB 3BTB
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Erythrocyte Differentiation Erythrocyte Homeostasis Secretion Bicarbonate Transport Myeloid Cell Homeostasis Developmental Process Erythrocyte Development Secretion By Cell Homeostasis Of Number Of Cells Myeloid Cell Differentiation Ammonium Transport Hemopoiesis Anion Transport Immune System Development Exocytosis Organ Development System Development Iron Ion Homeostasis Positive Regulation Of Bone Resorption Regulation Of Platelet Aggregation Protein Secretion Negative Regulation Of B Cell Proliferation Regulation Of Lymphocyte Activation Transition Metal Ion Homeostasis Multicellular Organismal Development Regulation Of Cell Activation Regulation Of Mast Cell Degranulation Anatomical Structure Development Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Platelet Activation Positive Regulation Of Tissue Remodeling Ion Transport Positive Regulation Of Leukocyte Apoptotic Process Cell Development Ion Homeostasis Regulation Of Mast Cell Activation Regulation Of Bone Resorption Negative Regulation Of B Cell Activation Regulation Of Regulated Secretory Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Mediated By Integrin One-carbon Metabolic Process Regulation Of Bone Remodeling Monovalent Inorganic Cation Transport Inorganic Anion Transport Regulation Of Immune System Process Immune System Process Homeostatic Process Regulation Of T Cell Activation
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	acidosis ae1 anion bicarbonate calnexin cotranslationally destination exchanger folded folding glycoproteins glycosylated hereditary interfere kae1 misfolded monitors ovalocytosis properly retrotranslocation slc26 southeast spherocytosis summarizes traffic trafficking transporters ubiquitinylation
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	acidosis ae1 anion bicarbonate calnexin cotranslationally destination exchanger folded folding glycoproteins glycosylated hereditary interfere kae1 misfolded monitors ovalocytosis properly retrotranslocation slc26 southeast spherocytosis summarizes traffic trafficking transporters ubiquitinylation
Tagcloud (Intersection) ?