ACTC1 and KPTN

Number of citations of the paper that reports this interaction (PMID 12019562)
9

Data Source:
HPRD (in vivo)

		ACTC1	KPTN
Gene Name		actin, alpha, cardiac muscle 1	kaptin (actin binding protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Nucleus Microtubule Organizing Center Actin Cytoskeleton Growth Cone Stereocilium Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Movement Of Cell Or Subcellular Component Actin Filament Organization Sensory Perception Of Sound
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	3 interactors: ACTC1 APP SRPK1
Entrez ID		70	11133
HPRD ID		00015	17241
Ensembl ID		ENSG00000159251	ENSG00000118162
Uniprot IDs		B3KPP5 P68032	Q9Y664
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cell Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly MRNA Processing Skeletal Myofibril Assembly Neuron Remodeling Sperm Chromatin Condensation MRNA Metabolic Process RNA Processing Cellular Copper Ion Homeostasis Positive Regulation Of Viral Genome Replication Copper Ion Homeostasis Suckling Behavior Cardiac Myofibril Assembly Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Sexual Reproduction Innate Immune Response Spermatid Nucleus Differentiation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Actin-myosin Filament Sliding Muscle Filament Sliding Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Actin-mediated Cell Contraction Reproduction Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Viral Genome Replication Cell Death Death Regulation Of Cell Cycle G2/M Phase Transition Cardiac Muscle Contraction Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Cardiac Muscle Tissue Morphogenesis
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?