CAPN1 and LAMTOR1

Number of citations of the paper that reports this interaction (PubMedID 12358155)
0

Data Source:
HPRD (two hybrid)

		CAPN1	LAMTOR1
Description		calpain 1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Membrane Raft Extracellular Exosome Ragulator Complex Ficolin-1-rich Granule Membrane FNIP-folliculin RagC/D GAP
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein-membrane Adaptor Activity GTPase Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway	Autophagosome Assembly Regulation Of Cell Growth Regulation Of Receptor Recycling Cytoplasmic Translation Endosome Organization Lysosome Organization Intracellular Protein Localization Negative Regulation Of Autophagy Regulation Of Cholesterol Efflux Endosomal Transport Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Lysosome Localization TORC1 Signaling Cholesterol Homeostasis Positive Regulation Of MAPK Cascade Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Cholesterol Import Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of TORC1 Signaling
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Neutrophil degranulation Regulation of PTEN gene transcription CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Amino acids regulate mTORC1
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Urate levels ( 31578528)
Interacting Genes		55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	8 interacting genes: ABCF3 CAPN1 CCDC90B CTAG1A CTAG1B EEF1A1 NLRP3 TRIM14
Entrez ID		823	55004
HPRD ID		00253	07933
Ensembl ID		ENSG00000014216	ENSG00000149357
Uniprot IDs		B2RDI5 B4DWH5 P07384	Q6IAA8
PDB IDs		1ZCM 2ARY 7W7O 7X79 8GX3	5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization	TRNA Threonylcarbamoyladenosine Metabolic Process Molecular Adaptor Activity
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