ACTC1 and ACTN4

Number of citations of the paper that reports this interaction (PMID 12042308)
23

Data Source:
HPRD (in vivo)

		ACTC1	ACTN4
Gene Name		actin, alpha, cardiac muscle 1	actinin, alpha 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways		Striated Muscle Contraction	Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)	Heart rate ( 23583979)
Protein-Protein Interactions		35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		70	81
HPRD ID		00015	05222
Ensembl ID		ENSG00000159251
Uniprot IDs		B3KPP5 P68032	O43707
PDB IDs			1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin	1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?